Systemic immune-inflammation index predicts the severity of coronary stenosis in patients with coronary heart disease
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Published on: January 28, 2020
Yehong Liu1, Ting Ye1, Liang Chen1,2
1Wuxi Clinical College of Anhui Medical University, Wuxi 214044, China.
Insights
The novel systemic immune-inflammation index (SII) is linked to coronary artery disease (CAD) severity. Higher SII levels predict more severe coronary stenosis, indicating its role as an independent risk factor.
Area of Science:
- Cardiology
- Immunology
- Inflammation Research
Background:
- Coronary atherosclerosis is a chronic inflammatory condition.
- Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP) assess inflammation and coronary artery disease (CAD) severity.
- The systemic immune-inflammation index (SII) is a novel marker, and its association with CAD is not well-defined.
Purpose of the Study:
- To evaluate the relationship between the SII and the severity of coronary artery disease (CAD).
Main Methods:
- 395 patients undergoing coronary angiography were analyzed.
- Patients were categorized into CAD (285) and non-CAD (110) groups.
- The SII was calculated as neutrophil count * platelet count / lymphocyte count.
Main Results:
- An SII cutoff of 439.44 showed the highest predictive power for CAD.
- An SII cutoff of 652.83 was most predictive of severe coronary stenosis.
- The SII demonstrated superior predictive ability for severe coronary stenosis compared to NLR, PLR, and CRP.
Conclusions:
- The systemic immune-inflammation index (SII) is identified as an independent risk factor for both the development and severity of coronary artery disease (CAD).
Background:
Coronary atherosclerosis is a systemic chronic inflammatory disease with variable occurrence and progression. Some laboratory parameters, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and C-reactive protein (CRP) level, are used to evaluate the degree of inflammation and the severity of coronary artery disease (CAD). The neutrophil*platelet/lymphocyte is a novel systemic immune-inflammation index (SII), and its relationship with the development and severity of CAD is unclear.
Objective:
To investigate the association between the SII and the severity of CAD.
Methods:
Three-hundred and ninety-five patients who underwent coronary angiography were enrolled; among whom, 285 patients were included in the CAD group and 110 patients were included in the non-CAD group according to the WHO guidelines. Patients with CAD were further divided according to the Gensini score into the severe coronary stenosis group and the mild coronary stenosis group. The SII was calculated using the following formula: neutrophil*platelet/lymphocyte.
Results:
When the cutoff value of the SII was set at 439.44, the predictive power of CAD was the highest, with a sensitivity and specificity of 64.6 and 68.2%, respectively. When the cutoff value of the SII was set at 652.83, the predictive power of severe coronary stenosis was the highest, with a sensitivity and specificity of 71.0 and 86.0%, respectively. The area under the curve of the SII in predicting severe coronary stenosis was greater than that of the NLR, PLR and CRP level.
Conclusion:
The SII is an independent risk factor for the occurrence and severity of CAD.
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