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Updated: Nov 9, 2025

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
The good and bad of adipose tissue macrophage exosomes in obesity
Andrew S Greenberg1, Andrew R Reeves1
1Obesity and Metabolism Laboratory, JM-USDA Human Nutrition Research Center at Tufts University, Friedman School of Nutrition Science and Policy at Tufts University, Tufts University School of Medicine, Boston, MA, USA.
Abstract:
Adipose tissue macrophages regulate adipose tissue inflammation and systemic insulin-glucose homeostasis. In a recent study by Ying et al. (2021), M2 polarized bone marrow-derived macrophages secreted exosomes containing miR-690 that, when administered to obese mice, improved glucose-insulin homeostasis. miR-690 reduced expression of Nadk, which decreased inflammation and improved insulin signaling.
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