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Published on: December 6, 2016
Diagnostic accuracy of screening questionnaires for obstructive sleep apnea in children: A systematic review and
Serena Incerti Parenti1, Andrea Fiordelli1, Maria L Bartolucci1
1Department of Biomedical and Neuromotor Sciences (DIBINEM), Section of Orthodontics, University of Bologna, Bologna, Italy.
Insights
This review found the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire (SRBD-PSQ) to be the most sensitive screening tool for pediatric obstructive sleep apnea (OSA). Further research is needed to confirm its real-world clinical utility.
Area of Science:
- Pediatric Sleep Medicine
- Diagnostic Accuracy Studies
- Systematic Reviews and Meta-Analyses
Background:
- Pediatric obstructive sleep apnea (OSA) is a prevalent condition requiring accurate diagnostic tools.
- Screening questionnaires are utilized to identify children at risk for OSA.
- Evaluating the diagnostic performance of these questionnaires is crucial for clinical practice.
Purpose of the Study:
- To systematically review and meta-analyze the diagnostic accuracy of screening questionnaires for pediatric OSA.
- To compare the sensitivity and specificity of validated questionnaires against polysomnography (PSG).
- To identify the most effective screening questionnaire for pediatric OSA.
Main Methods:
- Systematic literature search for studies comparing questionnaires with PSG in children (≤18 years).
- Quality assessment using the QUADAS-2 tool.
- Bivariate meta-analysis of sensitivity, specificity, and likelihood ratios for questionnaires meeting inclusion criteria (≥4 studies, AHI ≥1).
- Construction of summary receiver operator characteristic curves.
Main Results:
- 37 studies (20 questionnaires) were included for qualitative analysis; none were low quality.
- 13 studies and two questionnaires (SRBD-PSQ and OSA-18) met criteria for quantitative synthesis.
- SRBD-PSQ demonstrated higher sensitivity (0.76) compared to OSA-18 (0.56).
- OSA-18 showed higher specificity (0.73) than SRBD-PSQ (0.43).
Conclusions:
- The SRBD-PSQ is the most sensitive screening questionnaire for pediatric OSA based on an apnea-hypopnea index (AHI) ≥1 threshold.
- While SRBD-PSQ shows promising sensitivity, OSA-18 offers better specificity.
- Further high-quality studies are recommended to validate the SRBD-PSQ in diverse clinical populations.
Abstract:
This systematic review and meta-analysis evaluated the diagnostic accuracy of screening questionnaires for pediatric obstructive sleep apnea (OSA). Studies comparing any questionnaire with polysomnography for OSA detection in subjects aged ≤18 y were considered eligible for qualitative analysis. The quality assessment of diagnostic accuracy studies (QUADAS-2) tool was used for bias assessment. Only questionnaires adopted by at least four studies using the currently accepted diagnostic threshold of apnea-hypopnea index (AHI) ≥1 were included for further selective quantitative analyses. A bivariate meta-analysis was performed to calculate sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio; summary receiver operator characteristic curves were constructed. 37 studies (20 questionnaires) were eligible for qualitative analysis; none were considered of low quality. Among these articles, 13 studies and two questionnaires (sleep-related breathing disorder scale of the pediatric sleep questionnaire (SRBD-PSQ) and OSA-18) satisfied the criteria for quantitative synthesis. SRBD-PSQ had higher sensitivity (0.76) than OSA-18 (0.56), while OSA-18 exhibited higher specificity (0.73) than SRBD-PSQ (0.43). SRBD-PSQ performed well and was the most sensitive screening questionnaire using the diagnostic threshold of AHI ≥1 for pediatric OSA. However, further well-designed studies are still required to assess the role of SRBD-PSQ in real-world clinical populations.
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