Diagnostic accuracy of screening questionnaires for obstructive sleep apnea in children: A systematic review and

Serena Incerti Parenti1, Andrea Fiordelli1, Maria L Bartolucci1

  • 1Department of Biomedical and Neuromotor Sciences (DIBINEM), Section of Orthodontics, University of Bologna, Bologna, Italy.

Insights

This review found the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire (SRBD-PSQ) to be the most sensitive screening tool for pediatric obstructive sleep apnea (OSA). Further research is needed to confirm its real-world clinical utility.

Area of Science:

  • Pediatric Sleep Medicine
  • Diagnostic Accuracy Studies
  • Systematic Reviews and Meta-Analyses

Background:

  • Pediatric obstructive sleep apnea (OSA) is a prevalent condition requiring accurate diagnostic tools.
  • Screening questionnaires are utilized to identify children at risk for OSA.
  • Evaluating the diagnostic performance of these questionnaires is crucial for clinical practice.

Purpose of the Study:

  • To systematically review and meta-analyze the diagnostic accuracy of screening questionnaires for pediatric OSA.
  • To compare the sensitivity and specificity of validated questionnaires against polysomnography (PSG).
  • To identify the most effective screening questionnaire for pediatric OSA.

Main Methods:

  • Systematic literature search for studies comparing questionnaires with PSG in children (≤18 years).
  • Quality assessment using the QUADAS-2 tool.
  • Bivariate meta-analysis of sensitivity, specificity, and likelihood ratios for questionnaires meeting inclusion criteria (≥4 studies, AHI ≥1).
  • Construction of summary receiver operator characteristic curves.

Main Results:

  • 37 studies (20 questionnaires) were included for qualitative analysis; none were low quality.
  • 13 studies and two questionnaires (SRBD-PSQ and OSA-18) met criteria for quantitative synthesis.
  • SRBD-PSQ demonstrated higher sensitivity (0.76) compared to OSA-18 (0.56).
  • OSA-18 showed higher specificity (0.73) than SRBD-PSQ (0.43).

Conclusions:

  • The SRBD-PSQ is the most sensitive screening questionnaire for pediatric OSA based on an apnea-hypopnea index (AHI) ≥1 threshold.
  • While SRBD-PSQ shows promising sensitivity, OSA-18 offers better specificity.
  • Further high-quality studies are recommended to validate the SRBD-PSQ in diverse clinical populations.