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Related Concept Videos

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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Non-gated Ion Channels01:24

Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
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Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
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Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

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Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
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Related Experiment Video

Updated: Nov 9, 2025

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

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TRPV1 Ion Channel: Structural Features, Activity Modulators, and Therapeutic Potential.

Irina N Gladkikh1, Oksana V Sintsova1, Elena V Leychenko1

  • 1Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia.

Biochemistry. Biokhimiia
|April 8, 2021
PubMed
Summary

The Transient Receptor Potential Vanilloid 1 (TRPV1) channel

Keywords:
TRPV1 ion channelcapsaicin receptordrug developmentmultimodal activationstructural and functional studiestherapeutic targetvanilloids

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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
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Area of Science:

  • Molecular Biology
  • Neuroscience
  • Pharmacology

Background:

  • The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel's precise roles in organisms remain unclear.
  • Despite extensive research, its regulatory mechanisms and involvement in diseases require further elucidation.

Purpose of the Study:

  • To review recent advancements in TRPV1 research, focusing on structural and functional aspects.
  • To explore the diverse ligands and endogenous modulators of TRPV1.
  • To highlight TRPV1's potential as a therapeutic target for various diseases.

Main Methods:

  • Structural studies and mutagenesis experiments to identify TRPV1 features and ligand binding sites.
  • Review of existing literature on TRPV1 channel function, regulation, and therapeutic potential.

Main Results:

  • Recent studies have detailed TRPV1's structural characteristics and ligand interactions.
  • Endogenous agonists and antagonists fine-tune TRPV1 sensitivity to activators like heat and capsaicin.
  • TRPV1 is implicated in numerous physiological and pathological processes beyond pain.

Conclusions:

  • TRPV1 is a multifaceted ion channel with significant roles in health and disease.
  • Understanding TRPV1's structure-function relationships and ligand interactions is crucial.
  • TRPV1 presents a promising therapeutic target for conditions including diabetes, epilepsy, and pneumonia.