Related Experiment Video

Updated: Nov 9, 2025

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

24.9K

T1 mapping and conditional survival in paediatric dilated cardiomyopathy with advanced heart failure

Shashi Raj1, Richa Kothari2, N Arun Kumar3

  • 1Pediatric Heart Failure and Heart Transplantation, Department of Pediatric Cardiology, Narayana Institute of Cardiac Sciences, NH Health City, Bengaluru, India.

Cardiology in the Young
|April 8, 2021
PubMed

Insights

Native T1 mapping did not predict survival in pediatric dilated cardiomyopathy patients with advanced heart failure. This cardiac MRI technique, assessing myocardial fibrosis, showed no significant difference between survivors and those who died.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Cardiovascular Imaging

Background:

  • Myocardial fibrosis is a known predictor of adverse events in idiopathic dilated cardiomyopathy.
  • Cardiac Magnetic Resonance Imaging (CMR) with late gadolinium enhancement is used to detect myocardial fibrosis.
  • Native T1 mapping offers a non-contrast method to assess myocardial tissue characteristics.

Purpose of the Study:

  • To evaluate the utility of native T1 mapping in assessing myocardial fibrosis and predicting conditional survival in children and adolescents with advanced heart failure due to dilated cardiomyopathy.
  • To determine if native T1 values can differentiate outcomes in this pediatric population.

Main Methods:

  • Retrospective case-cohort study of patients aged 21 years or younger with advanced dilated cardiomyopathy (LVEF ≤ 45%, NYHA class ≥ 2) who underwent CMR.
  • Native T1 mapping was performed prior to contrast administration.
  • Conditional survival (≥ 6 months post-CMR) was assessed, including NYHA class and time to event (death or heart transplantation).

Main Results:

  • Fifty-seven patients (mean age 11.7 ± 6.1 years) were included, with a median NYHA Class III and LVEF of 25%.
  • The median native T1 was elevated at 1351 ms.
  • No significant difference in native T1 values was observed between patients who survived and those who died; multilevel regression analysis failed to predict 6-month conditional survival.

Conclusions:

  • Native T1 mapping, as assessed in this study, did not prove to be a reliable predictor of conditional survival in pediatric patients with advanced dilated cardiomyopathy.
  • Further research may be needed to explore other CMR parameters or refine native T1 mapping techniques for prognostic value in this population.

Keywords:
Advanced heart failureT1 mappingcardiac MRIconditional survivaldilated cardiomyopathy

More Related Videos

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.0K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

13.7K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
125
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
121
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
104
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
114