Related Experiment Video
Updated: Nov 9, 2025
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
755
Role of DNA Repair Variants and Diagnostic Radiology Exams in Differentiated Thyroid Cancer Risk: A Pooled Analysis
Monia Zidane1,2,3, Thérèse Truong1,2,3, Fabienne Lesueur4
1INSERM, Centre for Research in Epidemiology and Population Health (CESP), 94800 Villejuif, France.
Summary
Genetic susceptibility to radiation-induced thyroid cancer was investigated. Variants in CDH2, NFATc2, ENOSF1/THYS, RPA3, and MGMT genes are associated with differentiated thyroid cancer risk.
Area of Science:
- Genetics
- Oncology
- Radiation Biology
Background:
- Diagnostic procedures increasingly involve radiation, necessitating understanding of genetic factors influencing thyroid cancer risk.
- Genetic susceptibility plays a role in developing radiation-induced thyroid cancer.
Purpose of the Study:
- To investigate genetic susceptibility to radiation-induced differentiated thyroid cancer (DTC).
- To identify specific gene variants associated with DTC risk following radiation exposure.
Main Methods:
- Two case-control studies in France analyzed self-declared diagnostic radiology records.
- Thyroid radiation doses were estimated for 1,071 DTC cases and 1,188 controls.
- Genotyping focused on 5,817 single nucleotide polymorphisms (SNPs) in 571 DNA damage response and repair genes.
Main Results:
- A 1.02 odds ratio (OR) per milli-Gray (mGy) for thyroid radiation dose was observed.
- Significant associations were found between DTC and variants in CHD2, NFATc2, ENOSF1/THYS, and RPA3.
- An interaction between an MGMT variant and thyroid radiation dose was significant.
Conclusions:
- Variants in CDH2, NFATc2, ENOSF1/THYS, RPA3, and MGMT are implicated in differentiated thyroid cancer risk.
- CDH2, NFATc2, ENOSF1/THYS, and RPA3 variants show a novel association with DTC risk.
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