Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants

1.8K

Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
1.8K
Gene-Environment Interactions01:20

Gene-Environment Interactions

790
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
790
Human Genetics01:28

Human Genetics

1.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.0K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

732
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
732

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Epigenetic regulation of cocaine intake through dopaminergic control of cholinergic interneurons in male mice.

Nature communications·2025
Same author

Deletion or enhancement of alpha-2 nAChRs (Chrna2) induces unique lifespan behavioral deficits.

Neuropharmacology·2025
Same author

Targeting GPR3 as a novel approach for nicotine cessation therapeutic development.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2025
Same author

Advancing Science, Improving Health, and Saving Lives in an Evolving Research Landscape.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2025
Same author

A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research.

Journal of extracellular vesicles·2024
Same journal

Assessing circuit function in the developing <i>Xenopus</i> tadpole: a survey of the behavioral toolkit and underlying neural substrates.

Frontiers in behavioral neuroscience·2026
Same journal

Dawn of the dread: threatening cinematic virtual reality environments enhance general but not specific pavlovian-instrumental transfer.

Frontiers in behavioral neuroscience·2026
Same journal

Transcranial alternating current stimulation improves cognitive functions in healthy subjects through modifying frontoparietal and dorsal attention networks based on personalized individual theta frequency analysis.

Frontiers in behavioral neuroscience·2026
Same journal

Functional loss of PKMζ in the dorsal hippocampus potentiates the time-dependent increase in false contextual fear memory and impairs spatial recognition memory in mice.

Frontiers in behavioral neuroscience·2026
Same journal

Distinct orbitofrontal circuits with dorsal and ventral CA1 differentially regulate spatial memory and emotional behaviors.

Frontiers in behavioral neuroscience·2026
Same journal

Towards a neurophysiological model of kundalini: a theoretical framework informed by preliminary clinical observations.

Frontiers in behavioral neuroscience·2026
See all related articles

Related Experiment Video

Updated: Nov 9, 2025

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
08:47

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Published on: February 10, 2012

13.7K

Multidimensional Intersection of Nicotine, Gene Expression, and Behavior.

Yasmine Sherafat1, Malia Bautista1, Christie D Fowler1

  • 1Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, Unites States.

Frontiers in Behavioral Neuroscience
|April 8, 2021
PubMed
Summary
This summary is machine-generated.

Nicotine impacts brain function by targeting nicotinic acetylcholine receptors (nAChRs), altering gene expression and behavior. These changes can create a cycle of drug intake, highlighting nicotine

Keywords:
acetylcholineendogenous allosteric modulatorepigeneticsgene expressionnicotine addictionnicotine withdrawalnicotinic acetylcholine receptor (nAChR)

More Related Videos

Live Imaging of Nicotine Induced Calcium Signaling and Neurotransmitter Release Along Ventral Hippocampal Axons
12:19

Live Imaging of Nicotine Induced Calcium Signaling and Neurotransmitter Release Along Ventral Hippocampal Axons

Published on: June 24, 2015

9.2K
Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine
10:48

Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine

Published on: January 25, 2019

9.5K

Related Experiment Videos

Last Updated: Nov 9, 2025

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
08:47

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Published on: February 10, 2012

13.7K
Live Imaging of Nicotine Induced Calcium Signaling and Neurotransmitter Release Along Ventral Hippocampal Axons
12:19

Live Imaging of Nicotine Induced Calcium Signaling and Neurotransmitter Release Along Ventral Hippocampal Axons

Published on: June 24, 2015

9.2K
Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine
10:48

Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine

Published on: January 25, 2019

9.5K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • The cholinergic system is vital for numerous brain functions, including cognition, learning, and memory.
  • Nicotine, found in tobacco and e-cigarettes, directly interacts with nicotinic acetylcholine receptors (nAChRs) in the brain.

Purpose of the Study:

  • To review how nicotine exposure alters gene expression within the cholinergic system.
  • To explore the bidirectional relationship between nicotine-induced gene expression changes and drug-seeking behaviors.

Main Methods:

  • Review of existing scientific literature on nicotine's effects on the cholinergic system.
  • Analysis of studies detailing nicotine's impact on nAChR activation and downstream signaling.
  • Examination of research on gene expression alterations induced by nicotine.

Main Results:

  • Nicotine's activation of nAChRs triggers immediate and lasting cellular effects.
  • Nicotine exposure leads to significant changes in gene expression.
  • These gene expression changes can be bidirectional, influencing subsequent nicotine consumption.

Conclusions:

  • Nicotine's action on nAChRs initiates a cascade affecting gene expression and behavior.
  • Understanding these gene expression changes is key to addressing nicotine addiction.
  • The bidirectional nature of these changes contributes to the cycle of substance use.