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Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation

Le-Le Ma1, Hui-Min Liu1, Chuan-Hong Luo1

  • 1State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.

Frontiers in Pharmacology
|April 8, 2021
PubMed

Insights

Traditional Chinese Medicine (TCM) effectively treats COVID-19 symptoms and reduces mortality. This study explores TCM

Area of Science:

  • Integrative Medicine
  • Pathophysiology
  • Pharmacology

Background:

  • COVID-19 presents significant global health challenges.
  • Fever is a primary clinical manifestation of COVID-19.
  • Traditional Chinese Medicine (TCM) has demonstrated efficacy in managing COVID-19 patients in China.

Purpose of the Study:

  • To elucidate the pathophysiological mechanisms of fever.
  • To analyze the antipyretic mechanisms of TCM based on its chemical constituents and pharmacological actions.
  • To provide a scientific basis for developing TCM-based antipyretic therapies for COVID-19.

Main Methods:

  • Review and synthesis of existing literature on fever mediators and signaling pathways.
  • Analysis of the chemical composition and pharmacological properties of relevant TCM.
  • Connecting scattered evidence to deepen understanding of fever from pathological and physiological perspectives.

Main Results:

  • Detailed analysis of pyrogenic cytokines and fever mediators.
  • Description of humoral and neural pathways involved in fever signal transmission.
  • Identification of multiple mechanisms through which TCM exerts antipyretic effects.

Conclusions:

  • TCM offers a multi-faceted approach to fever management in COVID-19.
  • Understanding TCM's antipyretic actions can guide the development of novel therapeutic strategies.
  • Further research into TCM compound preparations holds potential for COVID-19 prevention and treatment.

Keywords:
COVID-19antipyreticbioactive componentsfevermechanismtraditional chinese medicine

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