Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

436
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
436
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

683
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
683
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

387
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
387
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

496
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
496
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

285
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
285
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

400
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
400

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Narrative Review of Dietary Interventions and Supplementation for the Prevention and Treatment of Atopic Dermatitis.

Current pediatric reviews·2026
Same author

Correction: The future of severe acute respiratory syndrome-coronavirus and coronavirus disease.

World journal of pediatrics : WJP·2026
Same author

The future of severe acute respiratory syndrome-cornavirus and coronavirus disease.

World journal of pediatrics : WJP·2026
Same author

Status Epilepsy Syndromes Made Easy: Pediatric Perspectives.

Children (Basel, Switzerland)·2025
Same author

Netherton syndrome: effect on ichthyosis linearis circumflexa with dupilumab.

The Journal of dermatological treatment·2025
Same author

Primary hyperhidrosis: an updated review.

Drugs in context·2025
Same journal

Perioperative immune-checkpoint inhibitors for muscle-invasive bladder cancer.

Drugs in context·2026
Same journal

Deucravacitinib in dermatology: current indication and existing off-label data.

Drugs in context·2026
Same journal

Primary Sjögren's syndrome-associated interstitial lung disease: a case report with favourable response to tocilizumab.

Drugs in context·2026
Same journal

Corrigendum: Rheological properties and clinical efficacy of a chemically modified hyaluronic acid for joint health enhancement.

Drugs in context·2026
Same journal

Corrigendum: New and emerging treatments for PBC-related pruritus.

Drugs in context·2026
Same journal

GLP1 receptor agonists in heart failure with preserved ejection fraction (HFpEF) - beyond weight loss: a condensed scientific review.

Drugs in context·2026
See all related articles

Related Experiment Video

Updated: Nov 9, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

687

Paediatrics: how to manage functional constipation.

Alexander Kc Leung1, Kam Lun Hon2,3

  • 1Department of Pediatrics, University of Calgary, and Alberta Children's Hospital, Calgary, Alberta, Canada.

Drugs in Context
|April 8, 2021
PubMed
Summary
This summary is machine-generated.

Pediatric functional constipation management involves a thorough evaluation to rule out organic causes. Polyethylene glycol is the first-line treatment, combined with non-pharmacological strategies for optimal outcomes.

Keywords:
bulky stoolshard stoolsinfrequent defecationlaxativespainful defecationpolyethylene glycol

More Related Videos

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

2.3K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.8K

Related Experiment Videos

Last Updated: Nov 9, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

687
Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

2.3K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.8K

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Review
  • Evidence-Based Medicine

Background:

  • Functional constipation is a prevalent and challenging pediatric condition.
  • Effective management strategies are crucial for improving children's quality of life.

Purpose of the Study:

  • To provide an updated narrative review on the evaluation, diagnosis, and management of childhood functional constipation.
  • To highlight current best practices and treatment recommendations.

Main Methods:

  • A comprehensive literature search was conducted using PubMed with the keyword 'functional constipation'.
  • The review included clinical trials, meta-analyses, randomized controlled trials, observational studies, and reviews in the English literature concerning the pediatric population.

Main Results:

  • Diagnosis relies on detailed history, physical examination, and Rome IV criteria, with attention to 'red flags' for organic causes.
  • Pharmacological therapy includes fecal disimpaction and maintenance using oral or rectal medications, with polyethylene glycol as the most effective laxative.
  • Non-pharmacological approaches like education, behavioral modification, and dietary interventions, when combined with medication, enhance treatment success.

Conclusions:

  • Polyethylene glycol is the primary choice for disimpaction and maintenance therapy.
  • Lactulose serves as a preferred alternative if polyethylene glycol is unavailable or not tolerated.
  • Maintenance therapy should extend for at least two months, with early intervention promoting a shorter treatment course.