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Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease

Kai-Lieh Lin1,2, Shang-Der Chen1,3,4, Kai-Jung Lin1

  • 1Center for Mitochondrial Research and Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Frontiers in Cell and Developmental Biology
|April 8, 2021
PubMed

Insights

Mitochondrial dysfunction contributes to cardiovascular diseases like heart attack and diabetes complications. Maintaining mitochondrial health through dynamics and quality control is crucial for preventing heart disease.

Area of Science:

  • Cardiology
  • Mitochondrial Biology
  • Cellular Metabolism

Background:

  • Cardiovascular diseases (CVDs) are a major global health concern.
  • Heart metabolism relies on mitochondria for energy production via oxidative respiration.
  • Mitochondria are vital for cellular processes, including reactive oxygen species (ROS) generation and survival, and are implicated in cardiac pathological remodeling.

Purpose of the Study:

  • To review current literature on mitochondrial remodeling and dynamics in cardiovascular diseases.
  • To highlight the role of mitochondrial dysfunction in various cardiac pathologies.
  • To emphasize the importance of mitochondrial homeostasis for cardiac health.

Main Methods:

  • Literature review of current research on mitochondrial dynamics and cardiovascular pathology.
  • Analysis of the role of mitochondrial function in cardiac adaptation and disease.
  • Examination of mechanisms of mitochondrial quality control, including autophagy.

Main Results:

  • Mitochondrial dysfunction is implicated in ischemia/reperfusion (I/R) injury, hypertension (HTN), and type 2 diabetes mellitus (DM) complications.
  • Impaired mitochondrial dynamics and quality control contribute to the pathogenesis of cardiac disorders.
  • Mitochondrial homeostasis is essential for maintaining cardiac health.

Conclusions:

  • Mitochondrial remodeling and dynamics are critical factors in cardiovascular disease.
  • Dysfunctional mitochondria play a significant role in the development and progression of CVDs.
  • Strategies targeting mitochondrial health may offer therapeutic potential for cardiovascular conditions.

Keywords:
cardiovascular diseasediabetic cardiomyopathyhypertensionischemic heartmitochondriamitochondrial haplogroupmitophagynucleus

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