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The effect of L-dopa on in vivo dopamine release from nigrostriatal bundle neurons
R W Keller1, W G Kuhr, R M Wightman
1Department of Behavioral Neuroscience, University of Pittsburgh, PA 15260.
Brain Research
|April 26, 1988
Abstract:
We have examined the impact of L-dihydroxyphenylalanine (L-DOPA) on the in vivo release of dopamine (DA) in rat striatum using carbon fiber voltammetry. L-DOPA caused a large increase in the DA released by nigrostriatal bundle stimulation. This was reduced by 94% in animals pretreated with intraventricular 6-hydroxydopamine. We conclude that L-DOPA increases depolarization-induced DA release from DA neurons.