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Serum Copper Level and Its Relation with Blood Pressure and Urinary Protein Level in Preeclampsia

S H Lisa1, Q S Akhter, A Nessa

  • 1Dr Saima Haque Lisa, Assistant Professor, Department of Physiology, Parkview Medical College, Sylhet, Bangladesh;

Mymensingh Medical Journal : MMJ
|April 8, 2021
PubMed

Insights

Serum copper levels are significantly higher in preeclampsia patients. Elevated copper is positively linked to increased blood pressure and urinary protein, suggesting its potential role in predicting preeclampsia risk.

Area of Science:

  • Obstetrics and Gynecology
  • Clinical Chemistry
  • Trace Element Research

Background:

  • Preeclampsia is a complex pregnancy disorder linked to oxidative stress.
  • Alterations in essential trace elements may influence preeclampsia development.

Purpose of the Study:

  • To evaluate serum copper (Cu) levels in preeclampsia patients.
  • To investigate the relationship between serum copper and blood pressure/urinary protein.

Main Methods:

  • Cross-sectional study comparing 30 preeclampsia patients with 30 healthy pregnant controls.
  • Serum copper levels measured using established laboratory methods.
  • Statistical analysis included unpaired Student's t-test and Pearson's correlation coefficient.

Main Results:

  • Serum copper levels were significantly higher (p<0.001) in preeclampsia patients compared to controls.
  • Serum copper showed positive correlations with systolic and diastolic blood pressure.
  • A positive correlation was observed between serum copper and urinary protein levels.

Conclusions:

  • Serum copper levels are elevated in preeclampsia and positively correlate with disease severity markers.
  • Early pregnancy serum copper estimation may aid in predicting preeclampsia risk.

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