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Updated: Nov 9, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Does epidural analgesia really enhance recovery in pediatric surgery patients?
Sara A Mansfield1, Jacob Woodroof2, Andrew J Murphy2,3
1Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA. sara.mansfield@stjude.org.
Insights
Epidural anesthesia (EA) in pediatric surgery significantly reduced early post-operative pain scores and systemic opioid use in patients undergoing laparotomy and thoracotomy. These findings highlight EA
Area of Science:
- Pediatric Anesthesiology
- Pain Management
- Surgical Outcomes
Background:
- Effective pain management is crucial for pediatric surgical patients.
- Epidural anesthesia (EA) is an option for regional analgesia in pediatric surgery.
- Limited data exists on EA benefits in specific pediatric surgical procedures like thoracotomy and laparotomy.
Purpose of the Study:
- To evaluate the benefits of epidural anesthesia (EA) in pediatric surgical patients undergoing major abdominal or thoracic surgery.
- To compare post-operative pain scores and systemic opioid requirements between patients receiving EA and those not receiving EA.
Main Methods:
- Retrospective review of pediatric patients undergoing thoracotomy or laparotomy between 2015 and 2020.
- Exclusion of patients with prior opioid use, urgent/emergent cases, hemodynamic instability, or surgical complications.
- Primary outcome measures included post-operative pain scores and systemic opioid administration (oral morphine equivalents per kilogram).
Main Results:
- EA was utilized in 81.6% of laparotomies and 77.3% of thoracotomies.
- EA was associated with significantly lower systemic opioid use on Post-Operative Days 0 and 1 for both laparotomy and thoracotomy.
- Patients receiving EA reported significantly lower average pain scores on Post-Operative Day 0 for both surgical types.
Conclusions:
- Epidural anesthesia use in pediatric surgery is linked to reduced pain scores.
- EA is associated with lower systemic opioid requirements in the early post-operative period.
- EA demonstrates a beneficial role in managing pain for pediatric patients undergoing laparotomy and thoracotomy.
Purpose:
We sought to determine the benefits of epidural anesthesia (EA) in pediatric surgical patients.
Methods:
This study is a single-institution retrospective review of EA for pediatric patients undergoing thoracotomy or laparotomy from 2015 to 2020. Patients with recent or chronic opioid use were excluded. Urgent or emergent cases, patients with hemodynamic instability, or those with surgical complications that significantly impacted their post-operative course were also excluded. The primary objectives were comparison of pain scores and systemic opioid use between those patients with EA and those without EA.
Results:
Epidural anesthesia was used in 151 (81.6%) laparotomies and 58 (77.3%) thoracotomies. EA use was associated with lower mean systemic opioid administration during the early post-operative period for laparotomy (POD#0-0.33 ± 0.3 oral morphine equivalents per kilogram (OME/Kg) with EA vs 0.93 ± 1.53, p < 0.001, POD#1-1.34 ± 1.79 OME/Kg with EA vs 2.61 ± 2.60, p < 0.001) and thoracotomy (POD#0-0.40 ± 0.37 OME/Kg with EA vs 0.68 ± 0.41, p = 0.008, POD#1-0.89 ± 0.86 OME/Kg with EA vs 2.02 ± 1.92, p < 0.001). There were no differences seen by POD#2. Average pain scores were significantly lower in patients with EA following laparotomy (POD#0-1.22 ± 0.99 with EA vs 1.75 ± 1.33, p = 0.008) and thoracotomy (POD#0-1.71 ± 1.13 with EA vs 2.40 ± 1.52, p = 0.04).
Conclusions:
The use of EA in pediatric surgery patients was associated with lower pain scores despite lower systemic opioid requirements in the early post-operative period.
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