Jove
Visualize
Contact Us

Related Concept Videos

Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

24.7K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
24.7K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

6.1K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
6.1K
Structural Steel Products01:24

Structural Steel Products

503
Structural steel products are created within a structural mill. The process begins with a beam blank that is reheated and then fed through a series of rollers. These rollers progressively shape the metal into its final form. Adjusting the spacings between the rollers allows for the production of different sections with the same nominal dimensions.
Once shaped, the steel's final form emerges as a continuous length, which is then segmented by a hot saw into manageable pieces. These segments...
503
Cytoskeletal Accessory Proteins01:13

Cytoskeletal Accessory Proteins

3.5K
The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
3.5K
Structural Protein Function01:56

Structural Protein Function

29.2K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
29.2K
Structural Protein Function01:56

Structural Protein Function

3.0K
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification, reliability, and validity of drug-drug interaction checkers in chronic diseases: A systematic review.

British journal of pharmacology·2026
Same author

The role of premorbid cognitive performance in the neuropsychological assessment of people with HIV in South Africa.

PloS one·2026
Same author

How pharmacokinetic/pharmacodynamic models can inform the development of new HIV medications.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same author

Nirmatrelvir-ritonavir versus usual care in at-risk adults with early SARS-CoV-2 infection in the UK, 2022-23: virological and immunological results of an open-label randomised trial (PANORAMIC).

The Lancet. Microbe·2026
Same author

Systematic effects of patient factors and scanner/protocol factors on a Restriction Spectrum Imaging (RSI) quantitative MRI biomarker for prostate cancer.

Cancer imaging : the official publication of the International Cancer Imaging Society·2026
Same author

Brain Structure of South African Children Born to Mothers on Dolutegravir Versus Efavirenz-Based Antiretroviral Therapy.

Journal of the Pediatric Infectious Diseases Society·2026
Same journal

Mapping Evolution of Molecules across Biochemistry with Assembly Theory.

Journal of chemical information and modeling·2026
Same journal

Structural Proteomics-Based Deciphering of Hydrophobic Packing Fingerprints Informing Protein Thermostability in TIM Barrels.

Journal of chemical information and modeling·2026
Same journal

Bridging between Structure-Based and Data-Driven Affinity Prediction.

Journal of chemical information and modeling·2026
Same journal

Reinforcement Learning-Driven Multiproperty Optimization in Molecular Design Using Multicontext Transcriptome Data.

Journal of chemical information and modeling·2026
Same journal

EnsembleCycPerm: Interpretable Modeling of Cyclic Peptide Permeability through Solvent-Dependent Conformational Ensembles.

Journal of chemical information and modeling·2026
Same journal

Resolving Conformational Preferences of Monosaccharides from <sup>1</sup>H and <sup>13</sup>C NMR Chemical Shifts Using an Integrated MD and QM Approach.

Journal of chemical information and modeling·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 9, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.5K

AUTOSTERE: Systematic Search for Scaffold Replacement Opportunities within Structural Databases.

Jonathan R Heal1, Joseph M Sheridan1, Manisha Kulkarni2

  • 1RxCelerate Limited, Dorothy Hodgkin Building, Babraham Research Campus, Babraham, Cambridge CB22 3FH, United Kingdom.

Journal of Chemical Information and Modeling
|April 8, 2021
PubMed
Summary
This summary is machine-generated.

Medicinal chemists can now explore new drug targets for existing scaffolds using the AUTOSTERE algorithm. This computational approach systematically identifies novel ligand-target interactions, accelerating drug discovery.

More Related Videos

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

7.0K
Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

1.2K

Related Experiment Videos

Last Updated: Nov 9, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.5K
Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

7.0K
Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

1.2K

Area of Science:

  • Computational chemistry
  • Drug discovery
  • Medicinal chemistry

Background:

  • Medicinal chemists often reuse known scaffolds, limiting exploration of novel drug targets.
  • Existing methods for scaffold exploration are often limited in scale and scope.

Purpose of the Study:

  • To develop a computational algorithm (AUTOSTERE) for systematic scaffold replacement and target identification.
  • To identify new drug targets for established chemical scaffolds.

Main Methods:

  • Designed the AUTOSTERE algorithm to assess scaffold replacement opportunities within a large database of ligand structures.
  • Evaluated potential designs within the original ligand's protein environment.
  • Applied the method to substituted triazolinone and pyridopyrimidine scaffolds.

Main Results:

  • Identified approximately 600 novel triazolinone-containing ligands for targets including HSP-90, cathepsin K, and TIE-2 kinase.
  • Discovered potential novel HIV reverse transcriptase inhibitors based on pyridopyrimidine cores, which were synthesized and validated.
  • Demonstrated the algorithm's ability to suggest new target opportunities for preferred chemistries.

Conclusions:

  • The AUTOSTERE methodology offers a powerful new approach for identifying novel drug targets for known chemical scaffolds.
  • This systematic, large-scale scaffold replacement strategy can significantly broaden drug discovery efforts.
  • The approach facilitates the exploration of less-conventional chemical cores for therapeutic potential.