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Acute Bilateral Neuroretinitis and Panuveitis in A Patient with Coronavirus Disease 2019: A Case Report

Seyedeh Maryam Hosseini1, Mojtaba Abrishami1, Ghodsieh Zamani1

  • 1Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Ocular Immunology and Inflammation
|April 8, 2021
PubMed

Insights

This case study details a recovered COVID-19 patient experiencing bilateral neuroretinitis and panuveitis. Ocular fluid analysis confirmed SARS-CoV-2, suggesting a link between COVID-19 and severe vision loss.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus disease 2019 (COVID-19) has been associated with various ocular manifestations.
  • Post-COVID-19 complications require further investigation, particularly concerning neurological and inflammatory conditions affecting vision.

Observation:

  • A 37-year-old male presented with severe bilateral vision loss one month after recovering from COVID-19.
  • Ocular examination revealed bilateral retinitis and panuveitis with significantly reduced visual acuity.
  • RT-PCR analysis of vitreous samples confirmed the presence of SARS-CoV-2 RNA.

Findings:

  • The patient was diagnosed with bilateral neuroretinitis and panuveitis.
  • SARS-CoV-2 was detected in the intraocular fluid, indicating potential direct or indirect ocular involvement.
  • The patient responded well to corticosteroid treatment.

Implications:

  • This case highlights a potential link between COVID-19 recovery and severe intraocular inflammation.
  • Intraocular sampling and testing for SARS-CoV-2 should be considered in patients presenting with new-onset uveitis or retinitis during the pandemic.
  • Further research is needed to understand the pathogenesis and long-term ocular consequences of COVID-19.

Keywords:
Severe acute respiratory syndrome coronavirus-2coronavirus disease 2019neuroretinitispanuveitisreverse transcyptase- polymerase chain reaction

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