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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Updated: Nov 9, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Bed sharing versus no bed sharing for healthy term neonates.

Rashmi R Das1, Mari Jeeva Sankar2, Ramesh Agarwal2

  • 1Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India.

The Cochrane Database of Systematic Reviews
|April 8, 2021
PubMed
Summary

This review found no studies evaluating the safety and efficacy of bed sharing for newborns. Further research is needed to understand the benefits and risks of infant bed sharing practices.

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Area of Science:

  • Neonatal care
  • Infant sleep practices
  • Public health

Background:

  • Global variations exist in infant sleeping arrangements, with bed sharing being a common practice.
  • Bed sharing may offer physiological benefits like improved cardiopulmonary stability and breastfeeding duration.
  • However, bed sharing is associated with an increased risk of sudden infant death syndrome (SIDS).

Purpose of the Study:

  • To assess the efficacy and safety of neonatal bed sharing.
  • To evaluate impacts on breastfeeding, SIDS incidence, hypothermia, mortality, and neurodevelopmental outcomes.

Main Methods:

  • Searched multiple databases (CENTRAL, PubMed, CINAHL, LILACS) for randomized controlled trials (RCTs) and quasi-RCTs.
  • Included studies on term neonates sharing a bed with their mother within 24 hours of birth.
  • Planned to use the GRADE approach for evidence certainty assessment.

Main Results:

  • A comprehensive search yielded 6231 records, with 2745 records screened after duplicate removal.
  • Six full-text studies were assessed but ultimately excluded as they did not meet eligibility criteria.
  • No studies met the inclusion criteria for this review.

Conclusions:

  • No eligible studies were found to evaluate the efficacy and safety of bed sharing in healthy term neonates.
  • There is a critical need for well-designed RCTs to assess outcomes like breastfeeding and SIDS risk.
  • Future research should include diverse populations and settings, particularly in regions where bed sharing is culturally prevalent.