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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
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Heart failure outcomes and Covid-19
Eberhard Standl1, Oliver Schnell1
1Forschergruppe Diabetes e.V. at Helmholtz Centre, Munich, Germany.
Diabetes Research and Clinical Practice
|April 8, 2021
Summary
Patients with pre-existing heart failure (HF) face double the mortality risk with COVID-19. COVID-19 survivors may develop new heart failure, requiring long-term monitoring and priority vaccination for HF patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Pre-existing heart failure (HF) significantly increases mortality risk in patients with coronavirus disease 2019 (COVID-19).
- COVID-19 is associated with endothelial and cardiac injury, potentially leading to new-onset HF.
- Myocardial injury is prevalent in COVID-19 survivors, even those with mild illness.
Purpose of the Study:
- To assess the impact of COVID-19 on patients with and without pre-existing heart failure.
- To investigate the cardiac pathology and long-term cardiac sequelae in COVID-19 patients.
- To inform clinical management and public health strategies for HF patients during the pandemic.
Main Methods:
- Review of existing literature and systematic echocardiographic studies in COVID-19 patients.
- Analysis of biomarker and imaging findings (including MRI) in COVID-19 patients.
- Evaluation of mortality rates and cardiac injury markers.
Main Results:
- COVID-19 patients with pre-existing HF have nearly double the mortality rate.
- Right ventricular dilatation is the most common cardiac pathology (39%) in COVID-19 patients.
- 55-70% of COVID-19 survivors show myocardial injury on MRI, indicating a high risk for developing HF post-infection.
Conclusions:
- COVID-19 poses a significant risk for new-onset heart failure and adverse cardiac outcomes.
- Long-term monitoring of cardiac function in COVID-19 survivors is crucial.
- Proactive HF management and priority COVID-19 vaccination for HF patients are recommended.
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