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The relationship between polymorphisms of microRNA and preeclampsia: A protocol for meta-analysis and bioinformatics
Tao Li1,2, Yihong Chen1,2, Yi Lai1,2
1Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education.
Background:
Preeclampsia has genetic correlation. Many studies have shown that microRNA (miRNA) polymorphism is highly associated with preeclampsia, but the results are inconsistent. The purpose of this study is to systematically evaluate the relationship between miRNA polymorphism and preeclampsia.
Methods:
In this study, the search time is set from the establishment of the database on January 2021. The search database include China National Knowledge Infrastructure (CNKI), Wanfang, VIP and China Biology Medicine disc (CBM), PubMed, EMBASE, and Web of Science, and the Cochrane Library. The subjects are case-control studies on the relationship between miRNA polymorphism and preeclampsia. The language is limited to English and Chinese. The data of the included study are extracted and the literature quality is evaluated by 2 researchers independently. The data are statistically analyzed through Stata 16.0 software. We also predicted the miRNA secondary structure and the binding sites of miRNA interaction with its target genes.
Results:
This review will be disseminated in print by peer-review.
Conclusion:
This study will provide evidence-based medicine to elucidate the genetic tendency of preeclampsia.
Ethics And Dissemination:
Private information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval will not be required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences.
Osf Registration Number:
DOI 10.17605/OSF.IO/MJY2X.
Insights
Genetic variations in microRNAs (miRNAs) may influence preeclampsia risk. This systematic review evaluates the association between miRNA polymorphisms and preeclampsia, aiming to clarify genetic links.
Area of Science:
- Genetics
- Molecular Biology
- Obstetrics
Background:
- Preeclampsia exhibits a genetic correlation, with microRNA (miRNA) polymorphisms frequently implicated.
- Existing studies on the association between miRNA polymorphism and preeclampsia yield inconsistent results.
- A systematic evaluation is needed to clarify this relationship.
Purpose of the Study:
- To systematically evaluate the association between microRNA (miRNA) polymorphisms and preeclampsia.
- To provide evidence-based medicine for understanding the genetic predisposition to preeclampsia.
Main Methods:
- A comprehensive literature search was conducted in multiple databases (CNKI, Wanfang, VIP, CBM, PubMed, EMBASE, Web of Science, Cochrane Library) up to January 2021.
- Included were case-control studies investigating the relationship between miRNA polymorphism and preeclampsia, limited to English and Chinese publications.
- Data extraction, quality assessment, and statistical analysis were performed independently by two researchers using Stata 16.0. miRNA secondary structures and gene interactions were also predicted.
Main Results:
- This section is intentionally left blank as the abstract does not contain specific results.
Conclusions:
- This systematic review aims to provide evidence-based insights into the genetic factors contributing to preeclampsia.
- The findings will help elucidate the genetic tendency of preeclampsia.
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