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PPAR-α Modulators as Current and Potential Cancer Treatments
Yan Tan1, Mina Wang1,2, Ke Yang1
1School of Traditional Chinese Medicine and School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Frontiers in Oncology
|April 9, 2021
Summary
Peroxisome proliferator-activated receptors (PPARs) show promise in cancer therapy. PPAR-alpha specifically influences cancer cell behavior, offering potential therapeutic strategies for various cancers.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Cancer is a leading global cause of death.
- Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid metabolism with roles in cellular processes relevant to cancer.
- PPAR-alpha (PPAR-α) is a nuclear receptor influencing carcinogenesis.
Purpose of the Study:
- To review the functions of PPAR-α in cancer.
- To discuss the therapeutic potential of PPAR-α modulators (agonists and antagonists) in cancer treatment.
Main Methods:
- Literature review of studies on PPAR-α and cancer.
- Analysis of PPAR-α's role in cancer hallmarks like proliferation, inflammation, and angiogenesis.
- Examination of current and potential clinical applications of PPAR-α targeting drugs.
Main Results:
- PPAR-α regulates key cancer cell behaviors including proliferation, differentiation, inflammation, and angiogenesis.
- PPAR modulators can impact eNOS activation and immune responses, relevant to cancer management.
- Emerging evidence supports PPAR-α's role in modulating carcinogenesis.
Conclusions:
- PPAR-α plays a significant role in cancer development and progression.
- PPAR modulators represent a promising therapeutic avenue for various cancers.
- Further research into PPAR-α agonists and antagonists could lead to novel cancer therapies.
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