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Related Concept Videos

Antimicrobial Proteins01:23

Antimicrobial Proteins

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
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Antimicrobial Peptide-Polymer Conjugates for Dentistry.

Sheng-Xue Xie1, Linyong Song1, Esra Yuca2

  • 1University of Kansas (KU), Lawrence, Kansas.

ACS Applied Polymer Materials
|April 9, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel dental adhesive by conjugating antimicrobial peptides (AMPs) to methacrylate monomers. This peptide-conjugated resin matrix effectively inhibited Streptococcus mutans and improved mechanical properties, offering a promising strategy against secondary caries and enhancing restoration durability.

Keywords:
Streptococcus mutansantimicrobial peptidebioactivitybioconjugationdental adhesivemechanical property

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Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Antimicrobial Peptides

Background:

  • Bacterial adhesion and growth at the composite/adhesive/tooth interface are primary causes of dental composite restoration failure.
  • Streptococcus mutans initiates dental caries by compromising adhesive integrity and demineralizing tooth structure.
  • Antimicrobial peptides (AMPs) show potential for preventing bacterial biofilms due to broad-spectrum activity and low resistance risk, but their dental application is limited.

Purpose of the Study:

  • To develop a novel dental adhesive system by covalently conjugating antimicrobial peptides (AMPs) to methacrylate monomers, avoiding limitations of nonspecific adsorption and peptide leakage.
  • To investigate the antimicrobial activity and mechanical properties of the resulting AMP-polymer conjugates in a dental adhesive matrix.
  • To provide a robust approach for creating bioenabled peptide adhesive systems with enhanced durability and antimicrobial efficacy for dental applications.

Main Methods:

  • Antimicrobial peptides (AMPs) were conjugated to methacrylate (MA) monomers using two different spacer domains to tailor flexibility.
  • The resulting MA-AMP monomers were copolymerized into dental adhesives to form AMP-polymer conjugates.
  • Antimicrobial activity against Streptococcus mutans and mechanical properties (compressive moduli) of the AMP-conjugated matrix were evaluated.

Main Results:

  • The AMP-conjugated resin matrix demonstrated significant antimicrobial activity against Streptococcus mutans.
  • Secondary structure analyses provided insights into the differential activity of conjugated peptides.
  • AMP-polymer conjugates exhibited higher compressive moduli compared to hydrogel analogues like polyHEMA, indicating improved mechanical properties.

Conclusions:

  • Covalent conjugation of AMPs to methacrylate monomers provides a robust method for developing fine-tuned, bioenabled peptide adhesive systems.
  • The developed AMP-conjugated dental adhesives possess both enhanced antimicrobial activity and improved mechanical properties.
  • This approach represents a critical advancement toward peptide-conjugated dentin adhesives for preventing secondary caries and increasing the durability of dental restorations.