Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modified dual label Schilling test for pancreatic exocrine function.

J W Leung1, R A Frost, R Burgess

  • 1Middlesex Hospital, London.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 13, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A prospective RCT comparing combined chromoendoscopy with water exchange (CWE) vs water exchange (WE) vs air insufflation (AI) in adenoma detection in screening colonoscopy.

United European gastroenterology journal·2019
Same author

Underwater polypectomy without submucosal injection for colorectal lesions ≤ 20 mm in size-a multicenter retrospective observational study.

Surgical endoscopy·2018
Same author

Clinical Trial of 24 Hours' Treatment with Glutathione Precursors in Acute Pancreatitis.

Clinical drug investigation·2016
Same author

The uterine myocyte as a target for prevention of preterm birth.

Facts, views & vision in ObGyn·2014
Same author

The water method significantly enhances patient-centered outcomes in sedated and unsedated colonoscopy.

Endoscopy·2011
Same author

Comparison of accessory performance using a novel ERCP mechanical simulator.

Endoscopy·2008

The modified dual-label Schilling test shows 88% specificity but only 50% sensitivity for detecting chronic pancreatic disease. This diagnostic test may miss significant cases of pancreatic cancer and pancreatitis.

Area of Science:

  • Gastroenterology
  • Diagnostic Medicine
  • Biochemistry

Background:

  • The dual-label Schilling test is used to assess vitamin B12 absorption.
  • A modified kit form of the test was developed by Amersham International plc.
  • Evaluating diagnostic test performance is crucial for clinical application.

Purpose of the Study:

  • To assess the diagnostic accuracy of the modified dual-label Schilling test.
  • To determine the test's specificity and sensitivity in patients with chronic pancreatic disease.

Main Methods:

  • The modified dual-label Schilling test was evaluated in two independent centers.
  • Results from 66 subjects were combined for analysis.
  • A cut-off ratio of 58Co/57Co of 0.52 was used, derived from 10 healthy volunteers.

Related Experiment Videos

Main Results:

  • The test demonstrated a specificity of 88% in distinguishing normal from abnormal results.
  • Sensitivity for detecting chronic pancreatic disease was low at 50%.
  • The test yielded normal results in 5 of 8 pancreatic cancer patients and 9 of 21 chronic pancreatitis patients.

Conclusions:

  • The modified dual-label Schilling test exhibits good specificity but poor sensitivity for diagnosing chronic pancreatic disease.
  • Further investigation is needed to understand the reasons for the test's low sensitivity.
  • Clinical utility of this test for pancreatic conditions may be limited.