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Magnetic Resonance Imaging for Drug Development.

Jeong Kon Kim1

  • 1Department of Radiology, Asan Medical Center University of Ulsan, Seoul, Republic of Korea. kim.jeongkon@gmail.com.

Advances in Experimental Medicine and Biology
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PubMed
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Magnetic Resonance Imaging (MRI) offers valuable functional and anatomical insights for drug development. This review highlights preclinical MRI biomarkers crucial for translational research, bridging animal and human studies.

Keywords:
Diffusion-weighted imagingDrug developmentDynamic contrast-enhanced imagingMagnetic resonance imaging

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Area of Science:

  • Biomedical Imaging
  • Pharmacology
  • Translational Research

Background:

  • Magnetic Resonance Imaging (MRI) provides high-resolution cross-sectional imaging for preclinical and clinical research.
  • Advanced MRI techniques like diffusion-weighted imaging and MR spectroscopy offer disease- and drug-specific functional information.
  • MRI facilitates translational research by enabling consistent study methods across animal models and human subjects.

Purpose of the Study:

  • To introduce and discuss commonly used preclinical MRI biomarkers for drug development.
  • To emphasize the value of these biomarkers in translational research.
  • To explore how MRI can quantitatively measure biological alterations in disease and treatment.

Main Methods:

  • Review of established and emerging MRI techniques (T2-weighted, diffusion-weighted, dynamic contrast-enhanced, MR spectroscopy).
  • Discussion of MRI biomarkers for assessing anatomical and functional changes.
  • Focus on applications in preclinical drug development and translational studies.

Main Results:

  • MRI serves as a versatile tool in drug development, providing both anatomical and functional data.
  • A variety of MRI biomarkers have been identified to quantitatively measure biological alterations.
  • MRI bridges the gap between preclinical and clinical research, enhancing the translation of findings.

Conclusions:

  • Preclinical MRI biomarkers are essential for quantitative assessment in drug development.
  • The ability of MRI to maintain consistent methodologies across species is key for translational success.
  • MRI is a powerful tool for advancing drug discovery and development through robust biomarker utilization.