Related Experiment Video
Updated: Nov 9, 2025

19:53
Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
Published on: March 1, 2015
106.1K
Exaggerated lower frontalis and glabella after Botox injection.
1Dermatology Tripoli, Tarabulus, Libya.
Journal of Cosmetic Dermatology
|April 9, 2021
Summary
Botulinum toxin injections, like Botox, can rarely cause forehead furrowing. This temporary side effect, often due to muscle compensation, typically resolves within weeks.
Area of Science:
- Cosmetic Dermatology
- Neurology
- Plastic Surgery
Background:
- Botulinum toxin (Botox) injections are widely used for cosmetic and therapeutic purposes.
- While generally safe and effective, rare adverse events require clinical awareness.
Purpose of the Study:
- To describe a rare side effect of botulinum toxin injections in the upper face.
- To inform clinicians about managing forehead complications post-injection.
Main Methods:
- Case report detailing a patient's experience with Azzalure (a type of botulinum toxin).
- Observation of forehead muscle activity and anatomical patterns.
Main Results:
- A patient developed a deep horizontal forehead furrow and glabella projection one week post-injection.
- This rare complication is hypothesized to result from overactivity of untreated adjacent muscles or unique forehead muscle anatomy.
Conclusions:
- The observed forehead furrow is a rare, temporary side effect of botulinum toxin.
- Expected resolution within weeks suggests a dynamic muscular cause.
- Clinicians should be aware of this potential complication and its likely self-limiting nature.
Related Concept Videos
Muscles for Facial Expressions
3.6K
The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
3.6K
Skeletal Muscle Relaxants: Adverse Effects
586
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
586
Skeletal Muscle Relaxants: Therapeutic Uses
719
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
719
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
891
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
891
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
681
Nondepolarizing neuromuscular blockers prevent the membrane depolarization of muscle cells and inhibit muscle contraction. These are usually administered with anesthetics to achieve complete muscle relaxation. Upon administration, these drugs first block the small, rapidly contracting muscles of the face and hands, followed by the larger muscles of the trunk and the intercostal muscles. The diaphragm is the last muscle to be affected.
Although all competitive neuromuscular blockers are designed...
Although all competitive neuromuscular blockers are designed...
681
Facial Feedback Hypothesis
367
Charles Darwin proposed that facial expressions are an evolutionary adaptation for communication. He argued that these expressions are not influenced by culture but are universal across species. For example, a snarling expression with exposed teeth signals a threat in many animals, including humans. Darwin also suggested that displaying an emotion can intensify the feeling. Smiling, for example, could enhance one's sense of happiness. This idea laid the foundation for understanding the role...
367

