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Updated: Nov 9, 2025

Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
[Differentiated complex treatment of Parkinson's disease considering atrophic changes of the brain]
V A Chipizubov1, V V Shprakh2, S I Petrov1,2
1Irkutsk Regional Clinical Hospital, Irkutsk, Russia.
Objective:
To develop and implement the tactics of the differentiated complex (medication in combination with surgery) treatment of the form of Parkinson's disease (PD) associated with dyskinesias, according to the severity of atrophic changes in the brain.
Material And Methods:
The study included 40 patients with PD associated with dyskinesias and motor fluctuations. Patients of the main group received medication and surgical treatment, patients of the comparison group received only medication. The patient's health was assessed every 3 months during 1.5 years. Three atrophy indices were proposed to describe atrophic changes in the brain.
Results:
We have determined the values of the indices when the complex treatment was optimal for patients.
Conclusion:
The results of the study are supposed to be used in the practice of neurologists and neurosurgeons.
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