[Progressive supranuclear paralysis with levodopa-induced dyskinesia].

Area of Science:

• Neurology
• Neurodegenerative Diseases

Background:

• Progressive supranuclear palsy (PNP) is a rare, fatal neurodegenerative disease typically affecting individuals over 60.
• Characterized by akinetic-rigid syndrome, falls, supranuclear ophthalmoplegia, pseudobulbar symptoms, and frontal dementia.

Observation:

• A clinical case of a 79-year-old patient diagnosed with progressive supranuclear palsy is presented.
• The patient exhibited oromandibular hyperkinesis, an involuntary movement disorder affecting the jaw and mouth.
• This specific symptom occurred during levodopa treatment.

Findings:

• The case highlights a less commonly reported side effect of levodopa in PNP patients.
• Oromandibular hyperkinesis may manifest as a complex motor symptom in advanced stages of the disease.
• Detailed clinical description of this presentation is provided.

Implications:

• Understanding levodopa's potential side effects is crucial for managing PNP symptoms.
• This case contributes to the literature on atypical motor manifestations in progressive supranuclear palsy.
• Further research may explore the mechanisms linking levodopa to hyperkinesis in neurodegenerative conditions.