Structure-activity correlations for antibacterial 1,5-benzodiazepine derivatives on gram-positive cells

The antibacterial activity of a set of 1,5-benzodiazepine derivatives against Staph, aureus and Strep, pyogenes has been correlated with structural features of the compounds examined. It is shown by means of substituent constants and regression analysis that the lipophilic character of the molecule is the most important factor in determining its activity. Electronic and steric effects appear to be quite important.