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Clinical and experimental approaches for imaging of acute kidney injury

Daisuke Katagiri1,2, Feng Wang3,4, John C Gore4

  • 1Division of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223 MCN, Nashville, TN, 37232, USA. dkatagiri@hosp.ncgm.go.jp.

Clinical and Experimental Nephrology
|April 9, 2021
PubMed

Insights

This review explores novel biomarkers and advanced imaging techniques for diagnosing and understanding acute kidney injury (AKI). It highlights how these methods aid in assessing kidney damage, risks, and prognosis in patients.

Area of Science:

  • Nephrology
  • Biomarkers
  • Medical Imaging

Background:

  • Acute kidney injury (AKI) involves complex molecular and cellular changes with diverse causes.
  • Novel damage biomarkers show promise but also limitations in clinical settings.
  • Recent advancements in imaging offer new ways to study kidney disease.

Purpose of the Study:

  • To review recent imaging studies focused on acute kidney injury.
  • To discuss the clinical utility of various imaging modalities for AKI.
  • To provide a comprehensive overview of imaging's role in AKI diagnosis and prognosis.

Main Methods:

  • Literature review of recent studies on imaging techniques for AKI.
  • Analysis of different imaging modalities and their applications.
  • Discussion of biomarker advantages and disadvantages in relation to imaging.

Main Results:

  • Imaging techniques provide insights into compositional, structural, and functional kidney changes in AKI.
  • Several imaging modalities show potential for comprehensive AKI analysis.
  • The utility of these techniques in clinical settings is under evaluation.

Conclusions:

  • Imaging plays a crucial role in understanding the heterogeneity of AKI.
  • Advanced imaging combined with biomarkers can improve AKI risk assessment, diagnosis, and prognosis.
  • Further research is needed to fully integrate these imaging tools into clinical practice.
Keywords:
Acute kidney injuryDamage biomarkersImaging techniques

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