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Death of a child associated with multiple overdoses of acetaminophen
K V Blake1, D Bailey, G M Zientek
1College of Pharmacy, Division of Pediatric Pharmacology/Toxicology, University of Florida, Gainesville.
Insights
A six-year-old child died from long-term acetaminophen overdosage despite treatment. This case highlights the dangers of excessive acetaminophen use and the need for public education on medication toxicity.
Area of Science:
- Pediatric Toxicology
- Clinical Case Study
Background:
- Acetaminophen (APAP) is a common over-the-counter medication.
- Accidental pediatric overdose can occur due to perceived safety and escalating doses for fever or pain.
Observation:
- A 6-year-old child received escalating doses of acetaminophen for measles-related fever and pain over three days.
- Upon admission, serum acetaminophen levels were significantly elevated (163 µg/mL at 11 hours post-dose) with a prolonged half-life of 15 hours.
Findings:
- Despite aggressive oral acetylcysteine therapy, the child developed hepatic and renal failure, seizures, and ultimately brain death.
- Autopsy revealed centrilobular hepatic and renal tubular necrosis consistent with acetaminophen toxicity.
- Opportunistic fungal infections (Aspergillus and Cryptococcus) were noted but deemed secondary to the primary toxicity.
Implications:
- This case underscores the critical risk of acetaminophen toxicity, even in children, from prolonged supratherapeutic dosing.
- Public education regarding the safe use of nonprescription medications like acetaminophen is crucial to prevent fatal outcomes.
- Healthcare providers should maintain vigilance for acetaminophen toxicity in pediatric patients presenting with severe symptoms after excessive medication exposure.
Abstract:
A case of long-term acetaminophen overdosage in a six-year-old child, which contributed to her death despite optimal medical management including oral acetylcysteine therapy, is reported. Acetaminophen 325 mg every six hours was prescribed for fever associated with measles. Believing that acetaminophen was nontoxic, the child's mother progressively increased the dose over three days, first in response to fever and subsequently for abdominal pain probably secondary to unrecognized acetaminophen toxicity. On admission to the hospital, the patient's serum acetaminophen concentration was 163 micrograms/mL (11 hours after the last dose); subsequently, the acetaminophen half-life was determined to be 15 hours. A course of oral acetylcysteine therapy (a loading dose of 140 mg/kg as the sodium salt followed by 70 mg/kg every four hours for 17 doses) was begun. Hepatic and renal failure developed within two days, followed by the onset of seizures, and brain death occurred on the 11th day. Autopsy findings consistent with acetaminophen toxicity included centrilobular hepatic and renal tubular necrosis. Aspergillis fumigatus and Cryptococcus neoformans isolates from pulmonary abscesses and bronchopulmonary lymph nodes, respectively, were an unexpected finding. However, in the absence of acetaminophen overdosage, death would have been unlikely. Cryptococcal lymphadenitis was believed to have been the initial febrile illness that was treated with supratherapeutic doses of acetaminophen. Fatalities in children from a single overdose of acetaminophen have been rare, and there is only one previous report of a fatality after long-term administration of multiple excessive doses. The lethal outcome in this case illustrates the need to educate the public on the potential toxicity of nonprescription medications.