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A Descriptive Study Exploring Semen Quality Among Indian Cancer Patients
Lohith Chengappa Appaneravanda1, Brigitte Gerstl1,2,3, Ashwini Nagaraju1
1Department of Reproductive Medicine, Gunasheela Surgical and Maternity Hospital, Bangalore, India.
Journal of Adolescent and Young Adult Oncology
|April 9, 2021
Summary
Indian men with testicular cancer exhibit lower semen quality and higher infertility risks compared to other cancer groups. This finding impacts oncofertility and medical counseling guidelines.
Area of Science:
- Reproductive Medicine
- Oncology
- Men's Health
Background:
- Cancer diagnosis and treatment can significantly impact male reproductive health.
- Understanding pre-treatment semen quality in cancer patients is crucial for fertility preservation.
- Limited data exists on semen parameters specifically among Indian men with various malignancies.
Purpose of the Study:
- To descriptively explore and compare semen quality parameters in Indian men diagnosed with different types of malignancies before cancer treatment.
- To assess variations in semen volume, sperm concentration, motility, and morphology across testicular, hematological, and other cancer groups.
- To compare these semen parameters against World Health Organization (WHO) established criteria for normal semen quality.
Main Methods:
- Retrospective analysis of pre-treatment semen analyses from 461 male cancer patients (aged 15-50) in India.
- Evaluation of semen volume, sperm concentration, motility (progressive), and normal forms (morphology).
- Statistical comparison of semen parameters between different cancer groups and against WHO (2010, 5th ed.) reference values.
Main Results:
- No significant differences in semen volume or progressive motility were observed between cancer groups; parameters were generally within WHO criteria.
- Sperm concentration was significantly lower in testicular cancer patients compared to hematological and other cancer groups.
- Testicular cancer patients showed a higher prevalence of semen disorders (e.g., Asthenozoospermia, Oligozoospermia, Azoospermia) compared to other groups.
Conclusions:
- Males with testicular cancer demonstrate poorer semen quality, increasing their risk of infertility.
- Findings highlight the need for tailored oncofertility counseling and management for Indian men with testicular cancer.
- This study contributes valuable insights into male reproductive health outcomes in the context of cancer within the Indian population.
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