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Prognostic Impact of Tumor Size on Pancreatic Neuroendocrine Tumor Recurrence May Have Racial Variance
Rui Zheng-Pywell1, Amanda Fang, Ahmad AlKashash
1From the Department of Surgery, University of Alabama at Birmingham, Birmingham, AL.
Pancreas
|April 9, 2021
Summary
Racial disparities exist in pancreatic neuroendocrine tumors (PNETs). Black patients presented with larger PNETs, but tumor size did not predict survival outcomes in this group, unlike White patients.
Area of Science:
- Oncology
- Surgical Oncology
- Health Disparities Research
Background:
- Pancreatic neuroendocrine tumors (PNETs) incidence is rising.
- Black patients exhibit poorer survival outcomes for PNETs.
- Existing research suggests potential racial disparities in oncologic outcomes.
Purpose of the Study:
- To investigate racial disparities in oncologic outcomes for patients with resected PNETs.
- To compare demographic, clinical, and survival data between Black and White patients with PNETs.
- To determine if tumor size predicts recurrence differently across racial groups.
Main Methods:
- Retrospective analysis of 151 patients with resected PNETs from 2010-2019.
- Comparison of demographic factors, tumor characteristics, and survival rates between racial groups.
- Statistical analysis to identify predictors of recurrence and survival.
Main Results:
- White males and Black females were more frequently diagnosed with PNETs (P=0.02).
- Black patients had larger median tumor sizes (30 mm vs 23 mm; P=0.02) but similar overall and disease-free survival compared to White patients.
- Tumor size predicted recurrence in White patients (HR, 1.02; P=0.01) but not in Black patients.
Conclusions:
- Black patients with PNETs at this institution presented with larger tumors.
- Increased tumor size was not a predictor of disease-free survival in Black patients.
- Findings highlight potential differences in PNET presentation and prognosis across racial groups.
