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Updated: Nov 9, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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Tumor suppressor gene DLC1: Its modifications, interactive molecules, and potential prospects for clinical cancer

Guanghui Ren1, Guorong Li1

  • 1Shandong Provincial Key Laboratory of Animal Resistant, School of Life Sciences, Shandong Normal University, Jinan, China.

International Journal of Biological Macromolecules
|April 9, 2021
PubMed

Insights

Deleted in liver cancer 1 (DLC1) is a tumor suppressor. This review explores DLC1

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The tumor suppressor gene Deleted in liver cancer 1 (DLC1) negatively regulates Rho GTPases.
  • DLC1 dysfunction is implicated in various solid tumors due to underexpression or inactivation.
  • Mechanisms include genomic alterations, epigenetic changes, degradation, altered phosphorylation, and localization issues.

Purpose of the Study:

  • To review the binding partners of DLC1 at the gene and protein levels.
  • To explore anticancer drugs targeting DLC1.
  • To highlight DLC1's potential as a diagnostic indicator and therapeutic target in cancer.

Main Methods:

  • Literature review of studies on DLC1 binding partners.
  • Analysis of existing and potential therapeutic strategies targeting DLC1.
  • Synthesis of information on DLC1's role in tumorigenesis and its interaction networks.

Main Results:

  • DLC1 interacts with various partners at both gene and protein levels.
  • Dysregulation of these interactions contributes to DLC1's tumor-suppressive function loss.
  • Several therapeutic strategies targeting DLC1 are being investigated.

Conclusions:

  • Understanding DLC1 binding partners is crucial for developing targeted cancer therapies.
  • DLC1 represents a promising target for novel cancer treatments and diagnostics.
  • Further research into DLC1 interactions may unlock new therapeutic avenues.
Keywords:
Binding partnersDLC1Tumor suppressor gene

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