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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
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RIFM fragrance ingredient safety assessment, 5- and 6-decenoic acid, CAS Registry Number 72881-27-7
Summary
This safety assessment confirms 5- and 6-decenoic acid is safe for use. It is not genotoxic, phototoxic, or a skin sensitizer, and poses no environmental risk.
Area of Science:
- Chemical safety and toxicology
- Environmental risk assessment
Background:
- 5- and 6-decenoic acid is used in various applications.
- Comprehensive safety data is required for regulatory compliance and consumer safety.
Purpose of the Study:
- To evaluate the safety of 5- and 6-decenoic acid across multiple toxicological endpoints.
- To assess environmental safety, including persistence, bioaccumulation, and toxicity.
Main Methods:
- Genotoxicity assessed via read-across from oleic acid.
- Toxicity endpoints (repeated dose, reproductive, respiratory) evaluated using the Threshold of Toxicological Concern (TTC).
- Skin sensitization assessed using the Dermal Sensitization Threshold (DST); phototoxicity evaluated via UV/Vis spectra; environmental safety assessed against IFRA standards.
Main Results:
- 5- and 6-decenoic acid is not expected to be genotoxic, phototoxic, or a skin sensitizer.
- Exposure levels are below the TTC for systemic toxicity and below the DST for skin sensitization.
- The material is not persistent, bioaccumulative, and toxic (PBT), with environmental risk quotients <1.
Conclusions:
- The existing data support the safe use of 5- and 6-decenoic acid as described in the safety assessment.
- No significant toxicological or environmental concerns were identified.
- The material meets regulatory standards for safety and environmental impact.
