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Related Concept Videos

Obsessive-Compulsive Disorder01:28

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Personality Disorders: Dependent and Obsessive-Compulsive01:24

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Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Abnormal behavior, often referred to as mental illness, results from changes in brain function that influence thought patterns, behaviors, and social interactions. Psychologists and psychiatrists typically assess abnormal behavior using three primary criteria: deviance, maladaptation, and personal distress, particularly when these traits persist over long periods.
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Related Experiment Video

Updated: Nov 9, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
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Cell cycle abnormality is a cellular phenotype in OCD.

Pravallika Manjappa1, Srinivas Balachander2, Safoora Naaz3

  • 1Molecular Genetics Lab, Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.

Asian Journal of Psychiatry
|April 9, 2021
PubMed
Summary
This summary is machine-generated.

Obsessive Compulsive Disorder (OCD) shows altered cell cycle regulation, with fewer cells in the G2/M phase in patients. This suggests a potential peripheral cell phenotype for OCD and predicts treatment response to serotonin reuptake inhibitors.

Keywords:
Cell cycleFluoxetineLymphoblastoid cellsOCD

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Psychiatry

Background:

  • Cell cycle regulation abnormalities are implicated in various psychiatric disorders.
  • Research on cell cycle regulation specifically in Obsessive Compulsive Disorder (OCD) is limited.
  • Common biological underpinnings across psychiatric conditions highlight cell cycle regulation as a potential shared mechanism.

Purpose of the Study:

  • To investigate cell cycle regulation in Obsessive Compulsive Disorder (OCD).
  • To examine the in vitro effects of fluoxetine, a common serotonin reuptake inhibitor (SRI), on cell cycle regulation in OCD.
  • To determine if cell cycle dysregulation serves as a peripheral cellular phenotype for OCD.

Main Methods:

  • Utilized lymphoblastoid cell lines (LCLs) from OCD patients and healthy controls.
  • Exposed LCLs to 10μM fluoxetine for 24 hours.
  • Quantified cell cycle phase distribution using flow cytometry.

Main Results:

  • OCD patient LCLs exhibited a lower proportion of cells in the G2/M phase compared to controls.
  • LCLs from OCD patients who did not respond to SRI treatment showed a lower percentage of cells in G2/M phase than responders.
  • These findings suggest cell cycle dysregulation as a potential peripheral marker for OCD.

Conclusions:

  • Cell cycle dysregulation may represent a peripheral cellular phenotype in Obsessive Compulsive Disorder.
  • The study provides novel insights into the cellular mechanisms underlying OCD.
  • Differential cell cycle patterns in response to fluoxetine may correlate with treatment outcomes in OCD patients.