Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observing Picomolar Protein Unfolding Using Resonance Light Scattering.

Biomolecules·2025
Same author

The reverse sequence of Aβ amyloid self-triggers isolated nano-fibers and oligomers in lipid environment.

Chemistry and physics of lipids·2025
Same author

Formation of gel and solid phases in acrylic cuvettes upon exposure to DMSO, oxygen and light: implications for fluorescence spectroscopy.

Methods and applications in fluorescence·2024
Same author

Aβ Amyloid Fibers Drastically Alter the Topography and Mechanical Properties of Lipid Membranes.

Langmuir : the ACS journal of surfaces and colloids·2023
Same author

Interfacial Aβ fibril formation is modulated by the disorder-order state of the lipids: The concept of the physical environment as amyloid inductor in biomembranes.

Biochimica et biophysica acta. Biomembranes·2023
Same author

Melittin-solid phospholipid mixed films trigger amyloid-like nano-fibril arrangements at air-water interface.

Biochimica et biophysica acta. Biomembranes·2022

Related Experiment Video

Updated: Nov 9, 2025

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.5K

Stitching together a nm thick peptide-based semiconductor sheet using UV light.

Alain Bolaño Alvarez1, Marcelo Pino1, Steffen B Petersen2

  • 1CIQUIBIC, Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, CONICET, Universidad Nacional de Córdoba, Argentina.

Colloids and Surfaces. B, Biointerfaces
|April 9, 2021
PubMed
Summary

Researchers developed semiconductor-like peptide nanosheets using Langmuir monolayers. These novel materials exhibit tunable conductivity based on molecular orientation and light-induced crosslinking, paving the way for advanced biosensors and neural interfaces.

Keywords:
Amphipathic nanosheet peptide monolayersLateral conductivityNanoconfined tyrosine crosslinkingPeptide backbone asymmetryPeptide semiconductor behavior

More Related Videos

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

29.8K
Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics
09:05

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Published on: June 29, 2020

5.4K

Related Experiment Videos

Last Updated: Nov 9, 2025

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.5K
Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

29.8K
Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics
09:05

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Published on: June 29, 2020

5.4K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biophysics

Background:

  • Langmuir monolayers enable 2D organization of amphiphilic molecules.
  • Peptide nanosheets offer potential for novel electronic applications.

Purpose of the Study:

  • To measure lateral and transverse conductivity in confined peptide nanosheets.
  • To investigate the semiconductor-like behavior of amphipathic peptide monolayers.
  • To explore the impact of molecular orientation and UV-induced crosslinking on conductivity.

Main Methods:

  • Langmuir monolayer technique for peptide organization.
  • Electrical conductivity measurements (lateral and transverse).
  • Brewster Angle Microscopy for monolayer heterogeneity monitoring.
  • UVB irradiation for inducing tyrosine crosslinking.

Main Results:

  • Two retro-isomer amphipathic peptides formed stable, semiconductor-like monolayers.
  • Lateral conductivity and current-voltage behavior varied due to peptide bond backbone orientation.
  • UVB light induced changes in conductivity, current-voltage characteristics, and monolayer heterogeneity.
  • Semiconductor properties were dependent on backbone orientation and tyrosine crosslinking.

Conclusions:

  • Peptide nanosheets can be designed with tunable semiconductor properties.
  • Molecular design, including backbone orientation and crosslinking, is crucial for electrical characteristics.
  • Potential applications include biosensing and neural interfaces.