DigiKnowIt News: Educating youth about pediatric clinical trials using an interactive, multimedia educational website

Alison E Parker1, Tracy M Scull1, Abigail M Morrison1

  • 1innovation Research & Training, Durham, NC, USA.

Insights

An interactive website, DigiKnowIt News, improved children's knowledge and confidence regarding clinical trials. This educational tool shows promise for increasing pediatric clinical trial participation.

Area of Science:

  • Pediatric Health Research
  • Clinical Trial Education
  • Health Communication

Background:

  • Pediatric clinical trials are crucial for developing child-specific treatments.
  • Recruitment challenges often hinder the progress of pediatric clinical trials.
  • Engaging educational tools are needed to inform children about clinical trial participation.

Purpose of the Study:

  • To evaluate the effectiveness of the interactive multimedia website, DigiKnowIt News, in educating children about clinical trials.
  • To assess the impact of the website on children's knowledge, attitudes, beliefs, and self-efficacy regarding clinical trials.
  • To measure participant satisfaction with the DigiKnowIt News website.

Main Methods:

  • A randomized controlled trial with 91 pediatric participants (mean age 10.92 years).
  • Participants were assigned to an intervention group (access to DigiKnowIt News) or a wait-list control group.
  • Knowledge, attitudes, beliefs, and self-efficacy were measured pretest and posttest (1 week later).

Main Results:

  • The intervention group demonstrated significantly greater knowledge about clinical trials compared to the control group.
  • Participants in the intervention group reported higher confidence in participating in clinical trials.
  • High levels of participant satisfaction were reported for the DigiKnowIt News website.

Conclusions:

  • An interactive, multimedia educational website can effectively enhance children's understanding and confidence related to clinical trials.
  • DigiKnowIt News shows potential as a tool to improve factors influencing pediatric clinical trial recruitment.
  • Educational interventions are valuable for addressing barriers to participation in pediatric research.

Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Nursing Clinical Information System01:27

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...