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Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis.

Xiao-Ning Zhao1, Quan Sun2, You-Qin Cao1

  • 1School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, China.

BMC Genomic Data
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PubMed
Summary

Genetic variations in apolipoprotein genes are linked to hyperlipidemia risk. Specific alleles of APOA5, APOA1, APOB, and APOE were identified as significant risk factors in this meta-analysis.

Keywords:
APOApolipoproteinGene polymorphismHyperlipidemiaMeta-analysis

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Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Metabolic Disorders

Background:

  • Hyperlipidemia is a key factor in cardio-cerebrovascular diseases.
  • Previous studies on apolipoprotein gene polymorphisms and hyperlipidemia show regional variations.
  • Uncertainty exists regarding the association of these polymorphisms across diverse populations.

Purpose of the Study:

  • To conduct a meta-analysis on the association between apolipoprotein gene polymorphisms and hyperlipidemia.
  • To clarify the impact of specific genetic variations on hyperlipidemia susceptibility.
  • To consolidate findings from various populations.

Main Methods:

  • A meta-analysis was performed on 59 relevant articles.
  • Data included 13,843 hyperlipidemia patients and 15,398 healthy controls.
  • Statistical analysis focused on odds ratios (OR) and P-values for gene polymorphisms.

Main Results:

  • Significant associations were found between hyperlipidemia and APOA5-1131 T>C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms.
  • Odds ratios (OR) were 1.996, 1.228, 1.444, and 1.710, respectively.
  • All identified associations were statistically significant (P < 0.05).

Conclusions:

  • The C allele of APOA5 1131 T>C is a risk factor for hyperlipidemia.
  • The A allele at APOA1-75 bp increases susceptibility to hyperlipidemia.
  • The T allele of APOB XbaI and the ε2 and ε4 alleles of APOE are risk factors for hyperlipidemia.