Related Experiment Video

Updated: Nov 9, 2025

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.6K

Carotid intima-media thickness in patients with hyperuricemia: a systematic review and meta-analysis

Li-Hui Peng1, Yue He2, Wang-Dong Xu3

  • 1Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, 1 Xianglin Road, Luzhou, 646000, Sichuan, China.

Aging Clinical and Experimental Research
|April 10, 2021
PubMed

Insights

Hyperuricemia is linked to increased carotid intima-media thickness, a marker of cardiovascular disease risk. This meta-analysis confirms this association, suggesting hyperuricemia patients may face higher cardiovascular event risks.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Metabolic Diseases

Background:

  • Cardiovascular events pose significant risks for hyperuricemia patients.
  • The precise role of serum uric acid in cardiovascular disease remains debated.
  • Carotid intima-media thickness (CIMT) is an indicator of subclinical atherosclerosis.

Purpose of the Study:

  • To investigate the association between hyperuricemia and carotid intima-media thickness.
  • To compare CIMT in individuals with and without hyperuricemia through a meta-analysis.

Main Methods:

  • A comprehensive meta-analysis was conducted using data from PubMed, Cochrane Library, Embase, and Web of Science databases.
  • Standard mean differences (SMD) and 95% confidence intervals (CI) were calculated to assess CIMT differences.
  • Sensitivity, subgroup, and meta-regression analyses were performed to address heterogeneity and publication bias.

Main Results:

  • Eight studies were included, revealing a significant increase in CIMT in hyperuricemia groups compared to controls (SMD = 0.264, 95% CI [0.161-0.366], P < 0.001).
  • Subgroup and meta-regression analyses did not identify significant sources of heterogeneity among factors like age, BMI, blood pressure, smoking, or diabetes.
  • Publication bias was assessed and found to be non-significant (Begg's test P = 0.174).

Conclusions:

  • Hyperuricemia is associated with increased carotid intima-media thickness.
  • This finding suggests that individuals with hyperuricemia may have an elevated risk of cardiovascular diseases.
  • Further research may elucidate the mechanisms linking hyperuricemia to vascular changes.
Abstract

Keywords:
Cardiovascular diseasesCarotid intima-media thicknessMeta-analysisUric acid

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.2K
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.6K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
98
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
175
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
141
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
99
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
600
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
130