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Phytochemicals against anti-diabetic complications: targeting the advanced glycation end product signaling pathway

Amna Parveen1, Razia Sultana2, Seung Min Lee3

  • 1College of Pharmacy, Gachon University, No. 191, Hambakmoero, Yeonsu-gu, 21936, Inchon, Korea. amnaparvin@gmail.com.

Archives of Pharmacal Research
|April 10, 2021
PubMed

Insights

Advanced glycation end products (AGEs) are implicated in diabetes. Natural products offer a therapeutic strategy by interacting with AGEs and their signaling pathways to manage diabetes and its complications.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Endocrinology

Background:

  • Advanced glycation end products (AGEs) play a significant role beyond diabetes complications.
  • Several modulators, including receptor for AGEs (RAGE), HMGB1, and inflammatory cytokines, interact with AGE signaling.
  • These interactions influence diabetes progression and related conditions.

Purpose of the Study:

  • To review the signaling pathways involving AGEs and their modulators.
  • To explore the interactions between natural product phytochemicals and AGEs/mediators.
  • To propose a multifaceted therapeutic approach for diabetes prevention and treatment.

Main Methods:

  • Literature review of signaling pathways.
  • Analysis of interactions between phytochemicals and AGEs/mediators.
  • Assessment of therapeutic potential of natural products.

Main Results:

  • AGEs signaling is complex, involving multiple interacting modulators.
  • Phytochemicals can modulate AGEs and related signaling cascades.
  • Natural products show promise in controlling and preventing diabetes.

Conclusions:

  • Targeting AGEs and their associated pathways with natural products presents a viable therapeutic strategy.
  • A multifold approach involving phytochemicals can help manage diabetes and its complications.
  • Further research into these interactions can lead to novel diabetes treatments.
Keywords:
Advanced glycation end productsCoronary artery diseaseDiabetesNitric oxidePhytochemicalsReactive oxygen speciesReceptor for advanced end product glycation

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