Auditory mismatch negativity in bipolar disorder: a focused review
Alberto Raggi1, Giuseppe Lanza2,3, Raffaele Ferri3
1Unit of Neurology, G.B. Morgagni - L. Pierantoni Hospital, Via Carlo Forlanini 34, 47121 Forlì, Italy.
Reviews in the Neurosciences
|April 10, 2021
Summary
Auditory mismatch negativity (MNN) is impaired in bipolar disorder, similar to schizophrenia. This suggests shared N-methyl-d-aspartate receptor dysfunction in both conditions, potentially aiding new treatment development.
Area of Science:
- Neuroscience
- Psychiatry
- Auditory Processing
Background:
- Auditory mismatch negativity (MNN) measures brain's echoic processing accuracy.
- MNN is linked to N-methyl-d-aspartate (NMDA) receptor activity.
- MNN is consistently impaired in schizophrenia.
Purpose of the Study:
- To investigate MNN in bipolar disorder (BD).
- To identify shared neurophysiological dysfunctions between BD and schizophrenia.
- To explore MNN as a potential biomarker for common psychopathology.
Main Methods:
- Focused literature review of 26 peer-reviewed articles.
- Analysis of studies indexed in PubMed.
- Synthesis of findings on MNN in bipolar disorder with psychotic features.
Main Results:
- Evidence indicates impaired MNN in bipolar disorder with psychotic features, though less severe than in schizophrenia.
- Some studies noted MNN abnormalities not specific to bipolar disorder.
- MNN research supports NMDA system involvement in bipolar disorder pathophysiology.
Conclusions:
- MNN research links schizophrenia and bipolar disorder via NMDA system involvement.
- MNN may serve as a biomarker for common psychopathology in these conditions.
- Further research could validate MNN as a correlate for schizophrenia and bipolar spectrum illnesses.
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