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Updated: Nov 9, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
Cutaneous involvement by T-cell prolymphocytic leukemia presenting as livedoid vasculopathy
Bruce D Leckey1, Meenal K Kheterpal2, M Angelica Selim1,2
1Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Abstract:
T-cell prolymphocytic leukemia (T-PLL) is a rare, aggressive neoplasm derived from post-thymic T-cells. Patients are typically middle aged with a slight male predominance who present with a high white blood cell count, hepatosplenomegaly, lymphadenopathy, and other symptoms typically associated with leukemia. Although cutaneous involvement has been reported in up to 30% of cases of T-PLL, to our knowledge, none have presented with a presentation resembling livedoid vasculopathy. In the correct clinical context, an underlying hematolymphoid neoplasm should be included in the differential diagnosis of a patient presenting with livedoid vasculopathy.
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