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Serum LRG1 as a novel biomarker for cardioembolic stroke
Meng Zhang1, Yuan Wang1, Jing Wang1
1Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Insights
Leucine-rich alpha-2 glycoprotein 1 (LRG1) shows potential in identifying cardioembolic stroke. Higher LRG1 levels indicate increased stroke severity and poorer prognosis.
Area of Science:
- Cardiology
- Neurology
- Biomarker Discovery
Background:
- Leucine-rich alpha-2 glycoprotein 1 (LRG1) is linked to cardiovascular conditions like atrial fibrillation and heart failure.
- The role of LRG1 in cerebral infarction remains debated.
- LRG1's potential in identifying cardioembolic stroke requires further investigation.
Purpose of the Study:
- To evaluate the diagnostic value of serum LRG1 levels for detecting cardioembolic (CE) stroke.
- To assess LRG1's correlation with stroke severity and short-term prognosis.
Main Methods:
- Serum LRG1 levels were measured using ELISA in 283 acute ischemic stroke (AIS) patients and 169 controls.
- AIS patients were categorized into CE and non-CE groups.
- LRG1's predictive performance was compared with established markers like BNP and LAD.
Main Results:
- Serum LRG1 levels were lower in AIS patients overall but higher in the CE group compared to the non-CE group.
- LRG1 demonstrated independent predictive value for CE stroke with an AUC of 0.768.
- A combined model of LRG1, BNP, and LAD significantly enhanced predictive accuracy.
- Elevated LRG1 correlated with greater stroke severity and poorer 3-month outcomes in CE patients.
Conclusions:
- Serum LRG1 is a promising biomarker for predicting cardioembolic stroke.
- LRG1 may also serve as an indicator for stroke severity and prognosis.
- Further research can explore LRG1's clinical utility in stroke management.
Background:
In recent years, LRG1 was found to be closely related to atrial fibrillation, heart failure, and myocardial remodeling after myocardial infarction. While its role in cerebral infarction was still controversial. We aimed to explore the value of LRG1 to identify the cardioembolic stroke.
Methods:
283 acute ischemic stroke(AIS) patients and 169 controls were enrolled. The AIS patients were divided into a CE(cardiogenic embolism) group and a non-CE group. Serum LRG1 levels were quantified by ELISA.
Results:
The serum LRG1 levels were decreased in the AIS patients. CE group had higher serum LRG1 levels than the non-CE group. LRG1 was an independent risk factor for cardioembolic stroke. The area under the curve (AUC) was 0.768 with a sensitivity of 72.5% and specificity of 69.5%, which was not second to BNP and LAD. The combined predictive model we designed, including LRG1, BNP, and LAD, greatly improved the prediction effect. A positive correlation was shown between LRG1 and stroke severity in the CE group. Those who experienced poor outcomes had higher serum LRG1 levels compared with good ones.
Conclusion:
Serum LRG1 was a promising indicator to predict cardioembolic stroke, as well as stroke severity and the 3-month prognosis of it.
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