RIFM fragrance ingredient safety assessment, ethyl 2-methyl-4-pentenoate, CAS Registry Number 53399-81-8

Area of Science:

• Chemical safety assessment
• Toxicology
• Environmental risk evaluation

Background:

• Ethyl 2-methyl-4-pentenoate is a fragrance ingredient requiring comprehensive safety evaluation.
• Existing data and read-across approaches are utilized to assess potential hazards.

Purpose of the Study:

• To evaluate the safety of Ethyl 2-methyl-4-pentenoate for consumer use.
• To assess genotoxicity, systemic toxicity, local respiratory effects, skin sensitization, phototoxicity, and environmental impact.

Main Methods:

• Read-across from methyl undec-10-enoate for genotoxicity assessment.
• Threshold of Toxicological Concern (TTC) for repeated dose, reproductive, and local respiratory toxicity.
• Dermal Sensitization Threshold (DST) for skin sensitization.
• UV/Vis spectroscopy for phototoxicity/photoallergenicity.
• Environmental risk assessment using PEC/PNEC ratios and PBT criteria.

Main Results:

• Ethyl 2-methyl-4-pentenoate is not expected to be genotoxic.
• Exposure levels are below TTC for systemic and local respiratory toxicity.
• Skin exposure is below the DST, indicating no sensitization potential.
• No phototoxicity or photoallergenicity is expected.
• The material is not Persistent, Bioaccumulative, and Toxic (PBT), with environmental risk quotients <1.

Conclusions:

• The safety assessment supports the current use of Ethyl 2-methyl-4-pentenoate.
• The material presents a low risk for genotoxicity, systemic toxicity, local respiratory effects, skin sensitization, and phototoxicity.
• Environmental risks are deemed acceptable based on current usage volumes and standards.