Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostatic carcinogenesis evoked by cellular interaction.

L W Chung1, S M Chang, C Bell

  • 1Department of Urology, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston 77030.

Environmental Health Perspectives
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Screening for non-gonococcal urethritis.

International journal of STD & AIDS·2003
Same author

Non-nucleoside reverse transcriptase inhibitors--an overview.

International journal of STD & AIDS·2003
Same author

Pubourethral sling simultaneous with radical retropubic prostatectomy for patients at high risk for postprostatectomy incontinence.

Prostate cancer and prostatic diseases·2002
Same author

Evaluation of the involvement of nitric oxide and substance P in reducing baroreflex gain in the genetically hypertensive (GH) rat.

Acta physiologica Hungarica·2002
Same author

Clinical and genetic heterogeneity in peroneal muscular atrophy associated with vocal cord weakness.

Journal of neurology, neurosurgery, and psychiatry·2002
Same author

Isolation of mycoplasma species from the lower respiratory tract of healthy cattle and cattle with respiratory disease in Belgium.

The Veterinary record·2002
Same journal

A New Start.

Environmental health perspectives·2026
Same journal

Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

Environmental health perspectives·2026
Same journal

Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

Environmental health perspectives·2026
Same journal

Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

Environmental health perspectives·2026
Same journal

Workflow for Statistical Analysis of Environmental Mixtures.

Environmental health perspectives·2026
Same journal

Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

Environmental health perspectives·2026
See all related articles

Prostatic fibroblasts drive cancer development and androgen response in a novel rat carcinosarcoma model. This study highlights the potential role of epigenetic factors in prostate carcinogenesis.

Area of Science:

  • Oncology
  • Urology
  • Cancer Biology

Background:

  • Prostate cancer development involves complex interactions between epithelial and stromal cells.
  • The role of prostatic fibroblasts in epithelial tumorigenicity and androgen responsiveness is not fully understood.

Purpose of the Study:

  • To establish a novel rat model for studying prostate carcinogenesis.
  • To investigate the mechanism by which prostatic fibroblasts influence epithelial growth, androgen responsiveness, and tumorigenicity.

Main Methods:

  • Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into syngeneic rats.
  • Characterization of induced tumors for composition (adenocarcinoma and fibrosarcoma) and androgen responsiveness.

Main Results:

Related Experiment Videos

  • Successful induction of carcinosarcoma, a mixture of adenocarcinoma and fibrosarcoma, in rats.
  • The induced tumors demonstrated androgen responsiveness.
  • Prostatic fibroblasts were identified as key determinants of epithelial growth, androgen responsiveness, and tumorigenicity.

Conclusions:

  • Prostatic fibroblasts play a critical role in determining epithelial behavior and tumorigenicity in prostate cancer.
  • This novel rat model provides insights into a new mechanism for prostate carcinogenesis.
  • Epigenetic pathways may be significantly important in the development of prostate cancer.