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Updated: Nov 9, 2025
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Thrombin generation is associated with ischemic stroke at a young age
Samantha J Donkel1, Karmen Pater1, Frank W G Leebeek1
1Erasmus MC, University Medical Center Rotterdam, Department of Hematology, the Netherlands.
Thrombosis Research
|April 10, 2021
Summary
Thrombin generation (TG) kinetics differ in young adults experiencing ischemic stroke (IS) or transient ischemic attack (TIA). Specific TG parameters like lag time are associated with IS risk in younger populations.
Area of Science:
- Cardiovascular Science
- Neurology
- Hematology
Background:
- Ischemic stroke (IS) in young adults presents unique etiological challenges.
- Thrombin plays a critical role in arterial disease development and progression.
- Understanding thrombin generation (TG) in young IS patients is crucial for identifying underlying mechanisms.
Purpose of the Study:
- To investigate the association between thrombin generation (TG) parameters and the occurrence of a first ischemic stroke (IS) or transient ischemic attack (TIA) in young adults.
- To analyze differences in TG kinetics between young IS/TIA patients and healthy controls.
Main Methods:
- A case-control study included 160 young patients (men ≤45 years, women ≤55 years) with a first IS or TIA and 160 age- and sex-matched healthy controls.
- Thrombin generation (TG) was assessed using the calibrated automated thrombogram (CAT) assay.
- Logistic regression analysis was employed to determine associations, with separate analyses for men and women.
Main Results:
- TG initiated earlier, peaked faster, and concluded sooner in IS/TIA patients compared to controls.
- Peak thrombin height was significantly higher in patients (227 nM) versus controls (179 nM) (p=0.02).
- Lag time (LT), time to peak (TTP), and time to tail (TTT) were significantly associated with IS/TIA risk (ORs ranging from 0.91-0.92). LT, TTP, and TTT were associated with IS in men but not in women.
Conclusions:
- Specific thrombin generation (TG) parameters are demonstrably associated with first-time ischemic stroke (IS) in young adults.
- These findings highlight the potential role of altered TG kinetics in the pathophysiology of IS in younger individuals.
- Further prospective research is necessary to fully elucidate the clinical significance and mechanistic role of TG in IS.
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