[Aggressive tumor progression during immunosuppressive therapy with abatacept]
J Lapoirie1, F Lefort2, E Mériglier1
1Service de médecine interne et maladies infectieuses, hôpital Saint-André, CHU de Bordeaux, 33000 Bordeaux, France.
La Revue De Medecine Interne
|April 11, 2021
Summary
Abatacept, used for rheumatoid arthritis (RA), may accelerate cancer progression by altering immune surveillance. This case highlights a potential risk in patients with inflammatory diseases and cancer.
Area of Science:
- Immunology
- Oncology
- Rheumatology
Background:
- Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a co-stimulatory molecule that inhibits T-cell activation.
- CTLA-4 blockade enhances antitumor immunity, while CTLA-4 agonists like abatacept treat inflammatory diseases such as rheumatoid arthritis (RA).
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