Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

70
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
70
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

106
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
106
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

96
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
96
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

175
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
175
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

74
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
74
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

76
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
76

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Burden and Predictors of Anaemia in Children 1 to 5 Years at the Ejura-Sekyedumase Municipality in Ghana.

Anemia·2026
Same author

Environmental exposures and pediatric kidney health.

Pediatric research·2026
Same author

Pharmacokinetics of Dolutegravir in Children With HIV With and Without Tuberculosis Coinfection Treated According to World Health Organization Dosing Guidelines.

Journal of acquired immune deficiency syndromes (1999)·2026
Same author

Population pharmacokinetics of pyrazinamide and ethambutol in children with tuberculosis with or without HIV.

Antimicrobial agents and chemotherapy·2026
Same author

IPNA's commitment to world kidney day 2026: caring for little kidneys and protecting the planet.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Multidisciplinary neonatal acute kidney injury provider perceptions and practice patterns.

Pediatric nephrology (Berlin, Germany)·2026

Related Experiment Video

Updated: Nov 9, 2025

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

1.6K

Paediatric nephrology in under-resourced areas.

Sushmita Banerjee1, Nivedita Kamath2, Sampson Antwi3

  • 1Calcutta Medical Research Institute, Kolkata, India. sushmitabanerj@gmail.com.

Pediatric Nephrology (Berlin, Germany)
|April 11, 2021
PubMed
Summary

Paediatric nephrology (PN) services in under-resourced areas face significant challenges due to limited health resources and data scarcity. Despite these hurdles, regional efforts and international support are improving PN care for children globally.

Keywords:
Kidney replacement therapyLow-income countryLow-middle–income countryPaediatric nephrologyUnder-resourced

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.1K
Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions
06:32

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions

Published on: June 13, 2025

304

Related Experiment Videos

Last Updated: Nov 9, 2025

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

1.6K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.1K
Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions
06:32

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions

Published on: June 13, 2025

304

Area of Science:

  • Global Health
  • Pediatric Nephrology
  • Resource Allocation

Background:

  • Nearly half the world's population, including 60% of children, resides in low- or lower-middle-income countries.
  • Pediatric nephrology (PN) is often deprioritized in health resource allocation within these regions.
  • This article examines progress and ongoing limitations in delivering optimal PN services in under-resourced areas (URA).

Purpose of the Study:

  • To explore advancements and persistent limitations in pediatric nephrology (PN) services for children in under-resourced areas (URA).
  • To identify key challenges and progress in global pediatric kidney care.

Main Methods:

  • Searched Medline, PubMed, and Google Scholar for PN disease epidemiology, outcomes, and service availability in URA.
  • Contacted International Society of Nephrology (ISN) and International Pediatric Nephrology Association (IPNA) offices for data.
  • Conducted two online IPNA membership surveys and contacted regional IPNA members for detailed information.

Main Results:

  • Scarcity of published data from URA, with reported PN disease prevalence, management, and outcomes differing from high-income regions.
  • Identified deficiencies in human resources and advanced diagnostic tools (fluoroscopy, imaging, microscopy, genetic studies).
  • Many essential drugs and kidney replacement therapies are inaccessible; however, regional initiatives and international support have advanced PN services and infrastructure.

Conclusions:

  • Equitable distribution and affordability of PN services remain critical challenges in URA.
  • Continued efforts in regional data collection, advocacy, and international partnerships are essential.
  • The goal is to optimize PN training, investigations, and treatments, aiming for global parity, focusing initially on preventable conditions.