Identification of intra-individual variation in intracranial arterial flow by MRI and the effect on computed
Xinke Liu1,2, Evan Kao2, Henrik Haraldsson2
1Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Insights
Intra-individual flow variation in phase-contrast MRI can reach 10%, impacting hemodynamic simulations. This variation significantly alters wall shear stress but has minimal effect on low shear areas.
Area of Science:
- Medical Imaging
- Computational Fluid Dynamics
- Biomedical Engineering
Background:
- Accurate hemodynamic simulations are crucial for understanding cerebrovascular diseases.
- Phase-contrast MRI (PC-MRI) is used to assess blood flow dynamics.
- Intra-individual variability in serial PC-MRI studies can affect simulation accuracy.
Purpose of the Study:
- To quantify intra-individual flow variation in serial 2D PC-MRI acquisitions.
- To evaluate the impact of this flow variation on patient-specific computational fluid dynamics (CFD) simulations.
- To determine the influence of flow variability on hemodynamic parameters, particularly wall shear stress.
Main Methods:
- Prospective study of 51 patients with unruptured intracranial aneurysms undergoing serial 2D PC-MRI.
- Flow and velocity parameters were extracted to assess reproducibility and variation.
- Patient-specific CFD simulations were performed using measured inlet flow data.
Main Results:
- Intraclass correlation coefficients for flow parameters ranged from 0.77 to 0.90, indicating good reproducibility.
- A 10% coefficient of variation (CV) in mean flow was identified.
- A 10% variation in inlet flow led to substantial changes in wall shear stress (up to 47.57%) but minor changes in low shear area (up to 2.79%).
Conclusions:
- A 10% intra-individual mean flow variation is detectable with serial PC-MRI.
- This flow variation introduces non-negligible alterations in calculated wall shear stress.
- The impact on low shear area in hemodynamic calculations is relatively small.
Objectives:
To determine the intra-individual flow variation in serially acquired studies, and the influence of this variation on subsequent hemodynamic simulations using the inlet flow as a boundary condition. Author: Kindly check and confirm whether the corresponding authors are correctly identified.Confirmed.
Materials And Methods:
This prospective study included 51 patients (37 females and 14 males) with unruptured intracranial aneurysms who have received more than three times follow-up of 2D phase-contrast MR. The flow and velocity parameters were extracted to calculate the reproducibility and variation. Patient-specific computational fluid dynamics simulations were performed using the measured flows.
Results:
Intraclass correlation coefficients for mean and maximum velocity and flow parameters ranged from 0.77 to 0.90. A 10% CV of mean flow was identified. Variations of 10% in inlet flow resulted in hemodynamic changes including 41.41% of peak systolic wall shear stress; 39.13% of end-diastolic wall shear stress; 2.79% of low shear area at peak systole; 2.12% of low shear area at end diastole: 47.57% of time-averaged wall shear stress; and 0.17% of oscillatory shear index.
Conclusion:
This study identified 10% of intra-individual mean flow variation on phase-contrast MR. Intra-individual flow variation resulted in a non-negligible variation in wall shear stress, but relatively small variation in low shear area in hemodynamic calculations.
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