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Milk Peptides as Novel Multi-Targeted Therapeutic Candidates for SARS-CoV2
H Pradeep1, Umme Najma1, H S Aparna2
1Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysuru, Karnataka, 570 006, India.
Abstract:
The COVID-19, an acute respiratory syndrome caused by SARS-CoV2 is a major catastrophic event of the twenty first century. Relentless efforts for the development of effective pharmaco-therapeutics are in progress but the respite is the development of effective vaccines. However, monotherapy might not always exhibit complete efficacy and may culminate in the rapid evolution of drug-resistant viral strains. Hence, simultaneous modulation of multiple druggable targets not only enhances therapeutic efficacy but also quell the prospects of mutant viruses. Currently, milk peptides have bloomed beyond just being a quintessential part of nutrition to prominent therapeutic implications in human health and diseases. Hence, we have focused on colostrum/milk peptides as they have already been acknowledged for their high potency, target specificity with significantly low or no side effects and bio-toleration. The results presented provide a conceptual strategy for the rational designing of prospective multitargeted peptide inhibitors for SARS-CoV2.
Insights
This study explores using milk peptides to create multi-target inhibitors against SARS-CoV-2. This approach aims to improve COVID-19 treatment efficacy and prevent drug-resistant viral mutations.
Area of Science:
- Biochemistry
- Pharmacology
- Immunology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a significant global health crisis.
- Current treatments, including vaccines, face challenges like incomplete efficacy and the emergence of drug-resistant viral strains.
- Monotherapy can accelerate the evolution of resistant viruses, necessitating alternative therapeutic strategies.
Purpose of the Study:
- To investigate the potential of colostrum/milk peptides as therapeutic agents against SARS-CoV-2.
- To propose a conceptual strategy for designing multi-targeted peptide inhibitors for enhanced antiviral efficacy.
- To address the limitations of monotherapy by exploring simultaneous modulation of multiple viral targets.
Main Methods:
- Literature review and conceptual analysis of milk peptide properties.
- Evaluation of existing research on milk peptides' therapeutic potential.
- Bioinformatic and molecular modeling approaches to conceptualize peptide inhibitor design.
Main Results:
- Milk peptides demonstrate high potency, target specificity, and excellent bio-toleration.
- Colostrum/milk peptides offer a promising foundation for developing novel antiviral agents.
- Conceptual framework for designing multi-targeted peptide inhibitors against SARS-CoV-2.
Conclusions:
- Milk peptides represent a viable therapeutic avenue for combating SARS-CoV-2.
- Multi-targeted inhibition strategies using peptides can enhance treatment efficacy and mitigate resistance.
- Further research into rational design of peptide inhibitors is warranted for effective COVID-19 therapeutics.
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