Related Experiment Video
Updated: Nov 9, 2025

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
Published on: June 2, 2014
Computational evaluation of interactions between olfactory receptor OR2W1 and its ligands
1Department of Pharmacology, Inje University College of Medicine, Busan 47392, Korea.
Abstract:
Mammalian olfactory receptors are a family of G protein‒coupled receptors (GPCRs) that occupy a large part of the genome. In human genes, olfactory receptors account for more than 40% of all GPCRs. Several types of GPCR structures have been identified, but there is no single olfactory receptor whose structure has been determined experimentally to date. The aim of this study was to model the interactions between an olfactory receptor and its ligands at the molecular level to provide hints on the binding modes between the OR2W1 olfactory receptor and its agonists and inverse agonists. The results demonstrated the modes of ligand binding in a three-dimensional model of OR2W1 and showed a statistically significant difference in binding affinity to the olfactory receptor between agonists and inverse agonists.
Related Concept Videos
Olfaction
The olfactory receptors are embedded in the cilia of the...
Physiology of Smell and Olfactory Pathway
The olfactory...
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with...
Olfactory Receptors: Location and Structure
Quantitative Aspects of Drug-Receptor Interaction

