Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bladder mass following bone marrow transplant for sickle cell disease: A diagnostic dilemma.

Clinical hematology international·2026
Same author

Excellent outcomes using a novel reduced intensity conditioning with thiotepa and post-transplant cyclophosphamide for HLA-matched related donor transplant in adolescents and adults with sickle cell disease.

Bone marrow transplantation·2026
Same author

Outcomes of hematopoietic stem cell transplantation in patients aged 70 years and older.

Bone marrow transplantation·2026
Same author

Associations Between Lifetime Stressor Exposure and Externalizing Problems in Youth at Risk for Huntington Disease.

Brain and behavior·2026
Same author

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview.

American journal of hematology·2026
Same author

Flat dose intravenous immunoglobulin primary infection prophylaxis in multiple myeloma patients on BCMA and GPRC5D bispecific antibody therapy: the Vanderbilt experience.

Frontiers in immunology·2026

Related Experiment Video

Updated: Nov 9, 2025

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.1K

Cerebral Hemodynamics and Executive Function in Sickle Cell Anemia.

Kemar V Prussien1,2,3,4, Bruce E Compas1,2,3,4, Rachel E Siciliano1,2,3,4

  • 1Department of Psychology and Human Development, Vanderbilt University, Nashville, TN (K.V.P., B.E.C., R.E.S., A.E.C.).

Stroke
|April 12, 2021
PubMed
Summary

Sickle cell anemia is linked to cognitive issues. Higher cerebral blood flow and oxygen extraction fraction correlate with poorer executive function in patients.

Keywords:
anemiabloodexecutive functionhemodynamicsoxygensickle cell

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

16.3K

Related Experiment Videos

Last Updated: Nov 9, 2025

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.1K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

16.3K

Area of Science:

  • Neurology
  • Hematology
  • Cognitive Neuroscience

Background:

  • Sickle cell anemia (SCA) patients often exhibit cognitive deficits, independent of overt cerebrovascular events.
  • Understanding the underlying mechanisms of these deficits is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the association between hemodynamic markers and executive function in individuals with SCA.
  • To test the hypothesis that elevated cerebral blood flow (CBF) and oxygen extraction fraction (OEF) are linked to reduced executive function.

Main Methods:

  • Utilized 3-Tesla brain MRI to assess anatomic structure, gray matter CBF, and global OEF.
  • Executive function was evaluated using the working memory index (Wechsler battery) and NIH Toolbox Cognition Battery tasks.
  • Statistical analyses included bivariate and multivariate models, controlling for covariates.

Main Results:

  • In 54 SCA participants (ages 6-31), higher CBF correlated with lower working memory and inhibitory control.
  • Elevated OEF was associated with slower processing speed.
  • Hematocrit showed a positive relationship with fluid cognition.

Conclusions:

  • Hemodynamic impairments, indicated by elevated CBF and OEF, are associated with executive function deficits in sickle cell anemia.
  • These findings highlight potential neurovascular mechanisms contributing to cognitive impairment in SCA.